Health
“Urgent need” for further research on Covid-19 antibody testing-expert
Experts say there is an “urgent need” for better quality research to evaluate the effectiveness of the Covid-19 antibody test.
Researchers said caution is “guaranteed” when using antibody tests for clinical decision making or surveillance in a population.
Trials published in The BMJ reviewed evidence for tests published prior to April 30.
Antibody tests-also called serology-look for antibodies in a person’s blood.
This indicates if they have been ill in the past.
An international team of researchers led by scholars at the McGill University Health Center in Montreal, Canada, examined data on all studies that measured the sensitivity and specificity of the Covid-19 antibody test.
The authors investigated 40 studies and raised concerns about “significant weaknesses” in the evidence behind the tests.
They said many of the studies were not peer-reviewed and most turned out to be at high risk of bias or unclear.
The sensitivity results for each study were combined and ranged from 66% to 97.8%, depending on the type of test method used. This means that 2.2% to 34% of patients with Covid-19 are missed in a related study.
Pooled specificities ranged from 96.6% to 99.7%, depending on the test method. That is, 3.4% to 0.3% of patients are falsely identified as having Covid-19.
“There is an urgent need for higher quality clinical studies to evaluate the diagnostic accuracy of Covid-19 serology,” the authors write.
However, scholars who commented on this study say that the findings may come from studies published by the end of April, which suggests that recent studies may be better designed, and many tests are time-consuming. Emphasized that it would improve with.
Meanwhile, another opinion published in the journal calls for more patient and public input for Covid-19 policymaking.
BMJ’s Patient Partnership Editor Tessa Richards and Patient Editor Henry Sawcroft said that patients, families, and front-line healthcare and social care professionals were not involved in decision making. Insist.”
“These inputs help mitigate the predictable negative effects of large-scale service reconfigurations and lockdowns, and the need to clarify which services are stopped and which remain accessible. Was emphasized.”
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