Health
World’s First Pig Heart Transplant Recipient Died of Heart Failure Instead of Organ Rejection
A surgeon at the University of Maryland concluded that David Bennett Sr., the world’s first American citizen to receive a recombinant pig heart, died of heart failure and was not caused by organ rejection. Bennett, 57, who suffers from end-stage heart disease, received a heart in January this year from Revivicor, a biotechnology company that produces genetically modified pigs. Organ transplants have shown for the first time that a genetically modified animal heart can function like a human heart without being immediately rejected by the body, doctors said after a rare and successful operation. But his death two months later cast doubt on the procedure. Previous researchers have pointed out the pig virus, a preventable infection associated with catastrophic effects on grafts, as a possible reason for his death.
Researchers now say that the transplanted pig’s heart worked well for several weeks and, even when carefully examined during autopsy, showed no typical signs of rejection by the patient’s body. The surgeon concluded that the patient died of heart failure. This could have been caused by a complex set of factors.
“Our findings on autopsy did not show evidence of rejection. Instead, we saw that thickening of the myocardium and subsequent hardening lead to diastolic heart failure. This is because the myocardium relaxes and the heart. Means that it could not be filled with blood. Varsity’s School of Medicine.
The team describes several factors that may have contributed to the development of heart failure, including the use of intravenous immunoglobulin, given twice to patients two months after transplantation to prevent rejection and infection. did.
The drug contains antibodies against pig cells that can interact with the pig’s heart and cause reactions that damage the heart muscle. The heart contains evidence of DNA from a latent porcine virus called porcine cytomegalovirus (pCMV), first detected weeks after surgery and then through a sensitive examination confirmed during autopsy of the organ. I also found out that there is.
“I think this is an important learning experience. We know what we know now and will change some of our practices and techniques in the future,” said Varsity Surgery. Professor Muhammad M. Mohiudin added.
The new discovery is in the midst of a report from the US Food and Drug Administration (FDA), which is considering approval of human clinical trials for organ transplants from pigs to humans.
The well-known transplant has “raised public awareness of the field,” and “this is the perfect time to talk to the general public,” clinical trials were conducted. A recent advisory board of the US FDA.
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