Health
United Arab Emirates scientists have found a genetic link to life-threatening conditions resulting from COVID-19 in children
Dubai: A new study led by scientists at the Mohammed Bin Rashid Medical and Health Sciences University (MBRU) and Aljarila Pediatric Hospital, with genetic and clinical data from dozens of Arab children in Dubai and Jordan. , Pointing out new genetic factors, may contribute to pediatric multisystem inflammatory syndrome (MIS-C), a rare life-threatening complication resulting from COVID-19 in children.
MIS-C is a rare but serious complication that can occur in children with COVID-19. This condition is characterized by severe inflammation (cytokine storms) that can affect multiple organs such as the heart, lungs, kidneys, brain, skin, eyes, and gastrointestinal organs. MIS-C is a life-threatening illness if not diagnosed and treated promptly. It is not yet clear why certain children develop this complication, but recent studies provide new evidence for potential genetic factors associated with MIS-C.
Damages immune-related genetic changes
This study analyzed clinical, laboratory markers, and genomic findings in 70 predominantly Middle Eastern children who had COVID-19. Forty-five of them met the MIS-C case definition, and 25 were instead included as “controls.” The patient was treated at the Aljarira Children’s Hospital and the University of Jordan Hospital in the United Arab Emirates from September 2020 to August 2021.
In this study, funded by the Al Jalila Foundation and published at the JAMA Network Open, children with MIS-C had rare and potentially damaging immunity compared to COVID-19 “control” children. It turns out that it is very likely to cause related genetic changes. No MIS-C. In addition, there was an association between genetic findings and disease onset and resistance to treatment.
“This is an important study, because the findings not only show comprehensive genetic profiling of MIS-C in children, but are also essential to characterize the genetic contribution to the disease. Not because patients with Arab backgrounds have long been underestimated in genetic research, said Dr. Walid Abhamor, Head of Pediatric Infectious Diseases Department at Al Jarilla Pediatric Hospital and Research Investigator. I am.
This study is a Dubai-based scientist at MBRU, the Aljarira Pediatric Hospital, the Department of Medical Education and Research, the Dubai Health Department, the Department of Pathology, and the Department of Pediatrics at the University of Jordan and the Specialty Hospitals of Jordan.
“Excellence in clinical care and discovery”
“This study, which involves all organizations of the Dubai Academic Health Corporation, demonstrates the corporation’s vision of facilitating collaboration and promoting clinical care and discovery excellence. This study is highly respected. It represents a template for future quality research that will have a positive impact on patients around the world, as evidenced by the publication of the findings in a scientific journal, “said the College Dean. One professor, Sreyman Al-Hamadi, said. Medicine at MBRU.
“This study provided researchers at Dubai Academic Health Corporation with the opportunity to participate in collaborative research involving multiple researchers from different institutions and organizations. Collaborative research is the development of new research skills and partnerships. It is always encouraged because of its many benefits, such as strengthening and building research capabilities in medical institutions, “said Dr. Hamda Hassan Kansaheb, Head of Medical Research, Department of Medical Education and Research, Dubai Health Department.” I am.
“Expansion of Genome Sequencing”
“The results of this study suggest that rare genetic factors are involved in MIS-C disease and highlight immune-related pathways that may be targets for intervention,” the Aljarira Pediatric Genomics Center said. Director and Genetics at MBRU.
“Hopefully, this adds to functionally characterize some of the identified genes, extend genomic sequencing to a more diverse population, and fully characterize the genetic status of this new disease entity. Will encourage research, “added Dr. Abu Tayun.
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