Health
Coronaviruses Can Infect Brain Cells, Johns Hopkins Researchers Find
Researchers at Johns Hopkins University, who use a “minibrain” made from human stem cells, have discovered that brain cells can be infected by coronaviruses. This indicates that COVID-19 can cause serious neurological problems.
University virologists, neurotoxicologists, and infectious disease specialists introduced SARS-CoV-2 particles into the mini-brain, which model the growing human brain, and the first pathogens infect and replicate cells. I have discovered what they believe to be proof.
“At this point, we don’t know which cells are infected. Is it a very specific subpopulation or just random?” Thomas Hearton, Senior Author and Chair of Evidence-Based Toxicology Research in Hopkins Bloomberg School of Public Health.. “We also don’t know if this leads to a kind of chronic infection, as only a few cells are infected with a low starting dose of viral particles.”
A previous report from Wuhan, China, where the COVID-19 pandemic began, suggests that 36% of infected patients experienced neurological symptoms such as impaired consciousness and dizziness. However, it is unclear whether the virus can infect human brain cells.
Using organoids, small tissue cultures made from human cells that simulate whole organs, Hopkins researchers have shown that specific neurons express the ACE2 receptor. They conclude that ACE2 provides a pathway to the brain in their study. It was published in last week’s journal ALTEX: Alternatives to Animal Experimentation.
The blood-brain barrier protects the brain from many viruses, but it is unclear whether coronaviruses can invade. Hartung OK. However, he said that severe inflammation, as observed in COVID-19 patients, could weaken the barrier.
He described the brain as an “immune privilege”, which means that the immune system does everything it can to save its organs from defense. But it also means that the immune system is unable to clear the brain infection. For example, doctors can get rid of HIV almost anywhere except the brain. Hartung The above.
“It’s very likely that you have a chronic brain infection with a coronavirus,” he said. “This means it could affect a new generation of diseases like Alzheimer’s.”
Another concern with SARS-CoV-2 is the effect of the virus on the developing brain. Researchers at the Paris Sacre University have discovered that the virus can cross the placenta of pregnant women. This is a concern because the embryo does not have a blood-brain barrier in early development.
Hopkins researchers say there is no evidence that the virus can cause developmental disorders, but Dr. Hartung He said that the mini-brain contains ACE2 receptors from early stages of development.
He said there is a lot to learn about how coronaviruses can affect the brain, the neurodevelopment of children born to mothers with COVID-19.
“This study is another important step in understanding how infectious diseases cause symptoms and whether drug treatment may address COVID-19 disease,” said Hopkins Medical College. Infectious disease team for research with a medical professor.
A mini-brain model called BrainSpheres was created four years ago. Bloomberg School of Public Health.. According to a college press release, these were the first “highly standardized” organoids of their kind to be mass-produced and used to model numerous diseases, including viral infections such as Zika, HIV and Dengue. It has been.
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