Early treatment of periodontal disease May Alzheimer’s disease progresses slowly

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• Studies have shown a link between Alzheimer’s disease and the types of bacteria known to cause periodontal disease.
• Alzheimer’s disease is a type of dementia that leads to loss of thinking and memory.
• Scientists believe that this bacterium can exacerbate the symptoms of Alzheimer’s disease by increasing inflammation.
• Treatment and prevention of periodontal disease may help slow the progression of Alzheimer’s disease.
• Good oral hygiene may also help prevent some other illnesses associated with this bacterium.

Fusobacterium ((((F. Nucreatum) Is a common bacterium associated with oral diseases such as periodontal disease, bad breath, tooth abscesses and oral cancer. In addition, it is associated with various diseases found elsewhere in the body, such as cancer, infections, and inflammatory conditions.

recently, study Was announced in Frontier of Aging Neuroscience We have discovered that it may also be associated with Alzheimer’s disease.

The Alzheimer’s Association Alzheimer’s disease is the most common cause of dementia and accounts for about 60-80% of all cases. It is a progressive condition with no cure.

People who have experienced Alzheimer’s disease gradually lose their memory and cognition, and eventually become so severe that they interfere with their daily functions. It is thought to be caused by the accumulation of beta-amyloid and tau protein in the brain, which damages and kills nerve cells.

First author Jake Jinkun ChenDMD, MDS, and PhD, Professor of Periodontology and Director of the Department of Oral Biology, Tufts University School of Dentistry, his team’s work done using mice, F. Nucreatum It can exacerbate Alzheimer’s disease by causing inflammation or staying in the brain and secreting pathological molecules.

“Our research is F. Nucreatum It can impair the memory and thinking of mice through certain signal pathways, “Chen said. “This is a warning sign for both researchers and clinicians.”

It may seem strange that the bacteria found in the mouth can have such a widespread effect, but Chen said, “Your mouth is really the gateway to your body.” rice field.

Chen further explained: F. Nucreatum Causes abnormal growth of microglial cells. Microglial cells are immune cells in the brain that usually remove damaged nerve cells and infections. This overgrowth of microglial cells causes an increase in the inflammatory response.

“Chronic inflammation or infection is considered to be an important determinant of cognitive decline that occurs as Alzheimer’s disease progresses,” Chen said.

Chen does not prove that periodontal disease can cause Alzheimer’s disease, but that if periodontal disease is not treated properly, it can exacerbate the symptoms of Alzheimer’s disease. Suggests.

In addition, treating periodontal disease in the early stages of Alzheimer’s disease can slow its progression.

Chen will someday test the bacterial load and the degree of symptoms, F. Nucreatum Monitor the course of the illness.

He finds this study important because most adults have periodontal disease and many later develop Alzheimer’s disease. Understanding how this type of bacterium affects Alzheimer’s disease helps dentists and neurologists better understand the interaction between these two conditions.

He adds that the next step in his study is to use specific microRNAs to target the major causes of Alzheimer’s disease, including the formation of amyloid plaques, tau protein deposition, and brain inflammation. increase.

His goal is to “find a robust and effective” one-go “approach that will lead to the discovery of effective, safe and efficient treatment strategies for Alzheimer’s disease.”

Chen said periodontal disease affects 47% of Americans over the age of 30, while Alzheimer’s disease now affects about 6.5 million people.

“Given the increasing work to investigate the relationship between the two, including this study, we take seriously the importance of maintaining good oral hygiene for people in order to maintain cognition and overall health. I hope you will accept it. “

Ana Karina MascarenhasBDS, MPH, DrPH, FDS RCPS (Glasg), Woody L. Hunt, Dean of the Faculty of Dentistry, El Paso, Texas Institute of Technology, said, “A hard-working, structured oral hygiene routine consisting of: :

• If possible, brush your teeth twice a day after eating. “This means the last thing after breakfast and before bedtime. Brushing after lunch is also helpful,” she said.
• Use fluoride toothpaste.According to this, it helps prevent tooth decay American Dental Association (ADA)).
• Avoid smoking tobacco products and vapors. Mascarenhas explained that these can increase the risk of inflammation and periodontal disease.
• Seek a dentist at least once a year... The ADA Regular medical examinations can help you detect problems early when the problem is easy and inexpensive to treat.
• Follow the dentist’s advice eagerly. This includes the use of mouthwashes and other recommended oral hygiene aids, Mascarenhas said.
• Get regular cleaning by a dental hygienist. Your dentist can recommend how often you do this based on your personal needs, she said.

Mascarenhas further advises that there are many other reasons to take care of your gums and teeth, even if you don’t have Alzheimer’s disease.

In addition to F. NucreatumPeriodontal disease, a new link to Alzheimer’s disease, is associated with several other diseases and its list continues to grow.

Certain cancers, preterm births, strokes, cardiovascular disease, and diabetes are associated with inadequate oral hygiene, she said.

She said there is ample evidence that patients with untreated periodontal disease are likely to be out of control of their condition, especially in the case of diabetes. “The consequences of uncontrolled diabetes are debilitating, including loss of limbs,” she said.

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