Exposure of embryos to environmental pollutants on the risk of diabetes, Health News, ET HealthWorld

Boston: School public health Alicia Timme-Laragy, associate professor of and Health Sciences, studies the effects of early exposure to two common perfluoroalkylators and polyfluoroalkylates (PFAS) Waterproof and non-adhesive household products, and PFAS-containing water-based film-forming foam (AFFF), About the developing pancreas. These so-called “eternal chemicals” pollute drinking water around the world and take decades to decompose in the environment.

According to Timme-Laragy, “many people are actively working to identify the long-term health effects of these substances.” We are trying to broaden our understanding of what these substances do. We believe that our models and procedures give us a very good opportunity to do so.

Transgenic zebrafish have been used by Timme-Laragy and her research team to investigate the effects of these toxic chemicals on embryonic development. John Clark, Professor of Environmental Toxicology, Faculty of Veterinary and Animal HusbandryBlood vesselsAt UMass, I’m also a member of the team.

In a living translucent zebrafish embryo, she claims, “you can observe the effects on very small cell populations in real time.” That is an exceptional opportunity.

This study shows that oxidative stress caused by exposure to chemicals causes abnormalities in developing islets, including beta cells (also known as cells) responsible for production, storage, and release. Insulin expands one of the.

Timme-Laragy uses state-of-the-art imaging techniques such as confocal microscopy to better understand these pathways and the functional effects of these abnormalities.

Type 1 and type 2 diabetes, obesity, pancreatitis, and pancreatic malformations are all associated with pancreatic malformations that affect an estimated 10% of the population. Preliminary findings reveal high levels of fructosamine, a clinical indicator of human diabetes, in zebrafish exposed to PFAS chemicals.

According to Timme-Laragy, “it clearly shows us that there are long-term effects on the development of diabetes.” “We understand the mechanism of functioning in beta cells and study specific fish with malformed islets, what effects they have on general growth and metabolism, and glucose homeostasis. I want to determine if there is. “

Familiarity with the mechanisms occurring within the cell will ultimately allow researchers to predict the effects of subsequent exposures. They also want to step up a series of studies on the adverse health effects of PFAS chemicals. (ANI)

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