Health

Manipulation of T cells to treat cancer patients

Bruce Feinberg, DO, describes how chimeric antigen receptor T cells were introduced into hematological malignancies.

Bruce Feinberg DO, Vice President and Chief Healthcare Officer at Cardinal Health Specialty Solutions, explains how the search for chimeric antigen receptor (CAR) T cells began.

In the 1980s, many researchers were still focused on finding treatments that could stop the cancer that invaded the body. However, with a better understanding that cancer originates from transforming human cells, the focus has shifted to finding treatments that can cope with host failure. According to Feinberg, this was the beginning of immunotherapy.

Later, in the mid-2000s, T cell manipulation was discovered after successful demonstrations with immune checkpoint inhibitors, Feinberg said.

Transcription:

0:07 | The story of CAR T goes back shortly before the drug was approved. Our view of cancer in general is the recognition that it was considered an invader. A way of thinking about bacteria and viruses to be the enemy we are trying to destroy. The perception that cancer has changed everything, rather than thinking of it as an enemy of external aliens, requires thinking of the problem a little differently, because cancer is made up of cells and they are changing human cells. There is an intruder, not a host failure. The story really begins when we think about empowering the immune system. Its first aspect dates back to the 1980s with interferon, interleukin, and tumor-infiltrating lymphocytes, which was the first round.

1:13 | The second method begins when we start thinking about teams using immune checkpoint inhibitors in mid-2000 and start thinking about manipulating T cells. Manipulation of T cells that begins with CAR T does not stop at CAR T. It can be seen that the empowerment of this host expands rapidly as it develops into bispecific antibodies and manipulates natural killer cells. , How does the immune system actually trigger to do its job and then control this process? This is actually a self-process as opposed to an external enemy.

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Manipulation of T cells to treat cancer patients

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