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Studies provide an important antigen map for SARS-CoV-2 mutants of concern

Studies provide an important antigen map for SARS-CoV-2 mutants of concern

 


Twenty different COVID-19 mutants were effectively identified and neutralized after the third booster, according to a new study from Sally University that provided an important antigen map of the mutant strains of concern.

The results of this study suggested that the immune system was weakened 20 weeks after vaccination, but the third booster (Phizer-BioNTech vaccine in this study) had 20 different immune systems. Helped identify and neutralize variants.

Antigen maps allowed the team to identify and measure how each variant affected the immune system.

The emergence of this disease and its devastating and deadly impact on our daily lives shows how important it is for the scientific community to work together to quickly identify and characterize infectious diseases. I have.


Sally’s contribution to this study through the mapping of different subspecies is animal and human health, and certainly a planet we all share. “


Dr. Daniel Houghton, co-author of the study and reader of veterinary virology at Sally University

The Pirbright Institute has led a collaborative study with scientists from Surrey University, Imperial College in London, and the UK Health Security Agency (UKHSA) to provide an immune response for individuals aged 70-89 years who have been vaccinated with the Pfizer BioNTech vaccine. understood.

This vaccine works by triggering the immune system to create a Y-shaped protein called an antibody that can attach to the peplomer protein on the surface of the coronavirus. When a person is infected with SARS-CoV-2, the antibody binds to the spike protein, preventing the virus from adhering to and invading human cells, helping to protect against severe illness. Antibodies also act as beacons that warn the immune system to help fight infections.

Dr. Dalan Bailey, Head of the Viral Glycoprotein Group at Pirbright, said:

“How to understand the level Neutralizing antibody Relevance to a well-defined immune response is an important step in understanding how the immune system responds to SARS-CoV-2 and may also help manage Covid-19. I have.

“This information may help us understand whether weakened immunity and new mutants increase the risk of breakthrough infections, hospitalizations, and deaths. Immune responses to various SARS-CoV-2 mutants. Comparing and understanding the role of various mutations is the management of Covid-19 pandemics and the prediction of the outcome of new variants. “

This study was published in Nature Microbiology.

sauce:

Journal reference:

Newman, J. , et al. (2022) Neutralizing antibody activity against 21 SARS-CoV-2 mutants in BNT162b2 vaccinated elderly. Nature Microbiology. doi.org/10.1038/s41564-022-01163-3..

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