Alcohol consumption and telomere length: Mendel’s randomization reveals the effects of alcohol

Vaiserman A, Krasnienkov D. Telomere Length as a Marker of Biological Age: State-of-the-art open issues, and future prospects. Front jennet. 2021; 11:1816.

paper

Google Scholar

Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, etc. Relationship between telomere length and risk of cancer and non-neoplastic disease: Mendel randomized study. JAMA Oncol. 2017; 3: 636–51.

paper

Google Scholar

Observational and genetic studies of short telomeres and Alzheimer’s disease in 67,000 and 152,000 individuals of Madrid AS, Rasmussen KL, Lord L, Frickeschmidt R, Nordestogard BG, Bojesen SE: Mendel randomization study. EurJ Epidemior. 2020; 35: 147–56.

paper

Google Scholar

Barrett EL, Richardson DS. Gender difference between telomeres and longevity. Aging cells. 2011; 10: 913–21.

CAS
paper

Google Scholar

Diez Roux AV, Ranjit N, Jenny NS, Shea S, Cushman M, Fitzpatrick A, etc. Racial / ethnicity and telomere length in multiethnic studies of atherosclerosis. Aging cells. 2009; 8: 251–7.

CAS
paper

Google Scholar

Lin X, Zhou J, Dong B. Effects of different levels of exercise on telomere length: systematic review and meta-analysis. J Rehab Remed. 2019; 51: 473–8.

paper

Google Scholar

Astuti Y, Wardhana A, Watkins J, Wulaningsih W. Smoking and telomere length: 84 studies and a systematic review of meta-analysis. Environ Res. 2017; 158: 480–9.

CAS
paper

Google Scholar

Strandberg TE, Strandberg AY, Saijonmaa O, Tilvis RS, Pitkälä KH, Fyhrquist F. Relationship between healthy middle-aged alcohol consumption and telomere length in older men. Helsinki businessman research. EurJ Epidemior. 2012; 27: 815–22.

paper

Google Scholar

Weischer M, Bojesen SE, Nordestgaard BG Telomere shortening independent of smoking, weight, physical activity, and alcohol intake: A general population of 4,576 people repeatedly measured at 10-year intervals. PLoS Genet. 2014; 10: e1004191.

paper

Google Scholar

Dixit S, Whooley MA, Vittinghoff E, Roberts JD, Heckbert SR, Fitzpatrick AL and more. Alcohol consumption and leukocyte telomere length. SciRep. 2019; 9: 1–10.

paper

Google Scholar

Effects of alcohol use disorders on aging of De Carvalho LM, Wiers CE, Manza P, Sun H, Schwandt M, Wang GJ, and other cells. Psychopharmacology. 2019; 236: 3245–55.

paper

Google Scholar

Wang H, Kim H, Baik I. Relationship between alcohol consumption, alcohol flash response and leukocyte telomere length in Korean adults. NutrResPract. 2017; 11: 334–9.

CAS
paper

Google Scholar

Gelernter J, Polimanti R. Genetics of substance use disorders in the age of big data. NatRevGenet. 2021; 22: 712–29.

CAS
paper

Google Scholar

Davey Smith G, Ebrahim S. “Mendel’s Law”: Can Genetic Epidemiology Contribute to Understanding the Environmental Determinants of Disease? IntJ Epidemior. 2003; 32: 1–22.

paper

Google Scholar

O’keefe EL, Dinicolantonio JJ, O’keefe JH, Lavie CJ Alcohol and CV Health: Jekyll and Hyde’s J-Curve. ProgCardiovascularDis. 2018; 61: 68–75.

paper

Google Scholar

Allen NE, Sudlow C, Peakman T, Collins R. UK Biobank Data: Come and get. SciTranslMed. 2014; 6:22.

paper

Google Scholar

Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, and other UK Biobank resources with deep phenotypes and genomic data. Nature. 2018; 562: 203–9.

CAS
paper

Google Scholar

Topiwala A, Ebmeier KP, Malulin-Sapey T, Nichols TE MRI markers of alcohol consumption and brain structure and function: A cohort study of 25,78 UK Biobank participants. Neuroimage Clin. 2022; 35.

Measurement and initial characterization of leukocyte telomere length in 474,074 participants from Cod V, Denif M, Swinfield C, Warner S, Papa Constantinople M, Chess S, and others UK Biobank. Nut aging. 2022; 2: 170–9.

paper

Google Scholar

Related studies of Liu M, Jiang Y, Wedow R, Li Y, Brazil DM, Chen F, and up to 1.2 million others provide new insights into the genetic causes of tobacco and alcohol use. Nut Jennet. 2019; 51: 237–44.

CAS
paper

Google Scholar

A multivariate Mendel randomized analysis investigating smoking and drinking in Gormley M, Dudding T, Sanderson E, Martin RM, Thomas S, Tyrrell J, and other oral and oropharyngeal cancers. Nut commune. 2020; 11: 1–10.

paper

Google Scholar

Bias due to participant duplication in Mendel randomization of Burgess S, Davis NM, Thompson SG 2 samples. Jennet Epidemioll. 2016; 40: 597–608.

paper

Google Scholar

A genome-wide meta-analysis of problematic alcohol use in Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, and others 435,563 individuals has been linked to biology and other traits. Brings insight. Nut neuroscience. 2020; 23: 809–18.

CAS
paper

Google Scholar

Codd V, Wang Q, Allara E, Musicha C, Kaptogee S, Stoma S and more. Polygene basis and biomedical consequences of telomere length changes. Nut Jennet. 2021; 53: 1425–33.

CAS
paper

Google Scholar

Verbanck M, Chen CY, Neale B, DoR. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendel randomization between complex properties and disease. Nut Jennet. 2018; 50: 693–8.

CAS
paper

Google Scholar

Hemani G, Tilling K, Davey, Smith G. GWAS summary data are used to direct causal relationships between inaccurately measured characteristics. PLoS Genet. 2017; 13: e1007081.

paper

Google Scholar

Doherty A, Smith-Byrne K, Ferreira T, Holmes MV, Holmes C, Pulit SL and more. GWAS identify 14 loci of physical activity and sleep time measured on the device. Nut commune. 2018; 9: 1–8.

CAS
paper

Google Scholar

Carvalho AF, Heilig M, Perez A, Probst C, Rehm J. Alcohol use disorder. The lancet. 2019; 394: 781–92.

paper

Google Scholar

Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S and more. A genome-wide association study of alcohol consumption and impaired use in 274,424 individuals from multiple populations. Nut commune. 2019; 10: 1–11.

paper

Google Scholar

Rosenström T, Torvik FA, Ystrom E, Czajkowski NO, Gillespie NA, Aggen SH and more. Prediction of Alcohol Use Disorders Using Personality Disorder Characteristics: Twin Studies. Addiction. 2018; 113: 15–24.

paper

Google Scholar

Li JJ, Savage JE, Kendler KS, Hickman M, Mahedy L, Macleod J, Other Polygene Risks, Personality Aspects, and Adolescent Alcohol Use Issues: Longitudinal Study. J stud alcohol drug. 2017; 78: 442–51.

paper

Google Scholar

Polimanti R, Peterson RE, Ong JS, Macgregor S, Edwards AC, Clarke TK and more. Evidence of the causal effect of major depression on alcoholism: findings from the Psychiatric Genomics Consortium. Psycho Med. 2019; 49: 1218–26.

paper

Google Scholar

Kamper-Jørgensen M, Grønbæk M, Tolstrup J, Becker U. Alcohol and cirrhosis: dose response or threshold effect? J Hepator. 2004; 41: 25–30.

paper

Google Scholar

Reichert S, Stier A. Does oxidative stress shorten telomeres in vivo? evaluation. Biol Lett. 2017; 13: 20170463.

paper

Google Scholar

Das SK, Vasudevan D. Alcohol-induced oxidative stress. life science. 2007; 81: 177–87.

CAS
paper

Google Scholar

Koch OR, Pani G, Borrello S, Colavitti R, Cravero A, Farrer S, and others Oxidative stress and antioxidant protection in ethanol-induced cell damage. MolAspMed. 2004; 25: 191–8.

CAS
paper

Google Scholar

Selective glutathione depletion of mitochondria by Correll A, Garcia Louis C, Miranda M, Aldite E, Mali M, Morales A, and other ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998; 115: 1541–51.

CAS
paper

Google Scholar

Gives BF. Correlation between Alcohol Use and DSM-IV Alcoholism Prevalence in the United States: Results of a National Longitudinal Alcohol Epidemiological Survey. J stud alcohol. 1997; 58: 464–73.

CAS
paper

Google Scholar

Dlouha D, Maluskova J, Lesna IK, Lanska V, Hubacek J. Comparison of leukocyte and relative telomere lengths measured in 11 different human tissues. Physiological resolution. 2014; 63: S343.

CAS
paper

Google Scholar