Health
The quest for a universal Covid-19 vaccine
In the mid-1980s, Jonathan Heaney was a doctoral student at the National Institutes of Health (NIH) in Maryland. He was told to fly to Oregon on the other side of the country to investigate the mysterious new disease that caused it. Sudden death spike in captive cheetah herds.
For Heaney, it proved to be the first known encounter with coronavirus. “We ultimately determined that this was a coronavirus that jumped into these cheetahs from domestic cats,” he says. “And because the cheetah was the new host, it caused a lot of death and destruction. That was my introduction to the cheetah.”
Four decades later, Heeney recently spearheaded DIOSynVax, a biotech company based in Cambridge, UK. Received a grant of $42 million (£34 million/€41 million) From foundations supported by the Coalition for Epidemic Preparedness Innovations (CEPI), Bill and Melinda Gates, the Governments of India and Norway, the World Economic Forum, and others.
Heaney and colleagues face a challenge that has long proven insurmountable for scientists. It’s about developing vaccines that can protect against not just a single coronavirus, but multiple strains, variants, and possibly entire families of them. Influenza has pursued the same goal for more than 20 years, but few have been worthy of note. Some even compare it to the infamous Manhattan Project of the 1940s.
An unprecedented amount of money is being thrown at the target. CEPI has an initial budget of approximately $200 million (£169m/€193m), further added by NIH $36 million (£30 million/€35 million) into the pan. Moderna, fueled by his success in developing one of his first Covid-19 vaccines, recently entered the fray, protecting against all four of his coronaviruses that cause the common cold. announced its intention to manufacture a vaccine that could
Heeney knows the road ahead better than anyone, having spent the last few years developing a single vaccine that can protect against a range of viral hemorrhagic fevers, including Ebola, Marburg virus and Lassa.
“We take a similar approach,” he says. “It’s all about structural biology, genetic relationships, looking at what these viruses change and what doesn’t.”
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