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Covid’s harmful effects on the brain last for years

Covid’s harmful effects on the brain last for years

 


Covid's harmful effects on the brain last for years

Coronavirus: Findings are based on records of over 1.25 million patients. (representative)

Covid-19 survivors remain at increased risk for psychotic disorders, dementia, and similar conditions for at least two years, according to large-scale studies.

Anxiety and depression occur more frequently after Covid than other respiratory infections, according to researchers at the University of Oxford, but risks usually subside within two months. Cognitive impairment, colloquially known as “brain fog,” epilepsy, seizures, and other long-term mental and brain health disorders, can occur after 24 months, according to a study published Wednesday in the journal Psychiatry. also continued to rise.

The findings, based on more than 1.25 million patient records, add evidence that the virus can severely damage the central nervous system and exacerbate the global burden of dementia. I started. Oxford researchers showed in March that even mild cases were associated with his decade’s worth of brain shrinkage in normal aging.

Professor of Psychiatry Paul Harrison said: “These results suggest that new cases of neurological disease associated with COVID-19 are likely to occur for some time after the pandemic subsides. It has important implications for patients and healthcare services because it is Lead author of the study, in a statement. The study highlights the need for further research to understand why this happens and what can be done to prevent and treat these conditions.

This study analyzed data on 14 neurological and psychiatric diagnoses from the TriNetXelectronic health record network. This data contains anonymized information about approximately 89 million patients, ranging from children to the elderly. The 1.28 million people with a confirmed Covid diagnosis during the two-year study period were matched with an equal number of patients with another respiratory infection to serve as a control group.

The odds of most neurological and psychiatric diagnoses after Covid were lower in children than in adults. It tended to be something

“worry”

Co-author Max Taket said, “The risk of depression and anxiety diagnoses is relatively high after the COVID-19 pandemic, and the good news is that there is no increased risk of these diagnoses in children. “But it is worrisome that some other conditions, such as dementia and seizures, continue to be diagnosed more frequently after Covid, even two years later.”

The fact that these risks remain elevated for so long suggests that the underlying mechanisms causing them persist after acute infection, the researchers said. include thrombus formation due to damage to the cells lining blood vessels, and leakage of the blood-brain barrier.

Prior vaccination is associated with reduced or unchanged risk for most neurological or psychiatric outcomes, the authors say. The incidence of these problems remains similar after the emergence of Omicron and Delta variants, suggesting that coronavirus infections may continue to cause neuropsychiatric illness even when they otherwise cause less severe disease. suggests that there is

In accompanying comments, Jonathan Rogers and Glynn Lewis of University College London said the study looks at some of Covid’s varied and lingering neurological and psychiatric effects in a large dataset. This is my first attempt to do so.

“This highlights several clinical features that particularly merit further investigation,” they said, adding that further studies are needed to validate the findings.

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