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US study finds diabetes drug metformin may halve risk of death from Covid

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widely available Studies show that metformin may reduce the risk of emergency room visits, hospitalizations, and death from COVID-19 by more than half when taken within four days of the onset of symptoms.

Researchers at the University of Minnesota in the United States noted that metformin, also known as glucophage, was used as an antiviral drug called “fluamine” in the 1950s.

Recent studies have found that the drug affects inflammatory pathways, they said.

Because COVID-19 involves viral inflammation, the research team thought the combination of anti-inflammatory and antiviral effects would be interesting enough to test this drug.

“When we learned that people taking metformin got COVID-19 less often and were hospitalized less, this was very interesting to us,” said the California-based nonprofit. Elaine Lissner, founder of the for-profit Parsemus Foundation, said.

The study, published Thursday in the New England Journal of Medicine, compared three drugs that were considered promising: fluvoxamine, an antidepressant that had shown strong results in previous studies, ivermectin, and many others. of interest, metformin.

The study included 1,323 participants at the highest risk of serious outcome in order to get life-saving results more quickly.

The researchers noted that metformin, a very cheap drug, could cut serious consequences by more than half if given immediately to people at high risk of COVID.

“Metformin is an incredibly common drug, taken by millions of people worldwide. ‘ said the listener.

According to researchers, metformin was the fourth most prescribed drug in the United States in 2019, with more than 85 million prescriptions written for more than 17 million patients.

US drug regulator FDA guidelines state that metformin should not be given to people with advanced kidney disease and should be taken with food or in a slow release formulation to avoid stomach upset. there is, they say.

Side effects are minor and include loose stools. Metformin is also considered safe for use in pregnant women, the researchers added.

(Only the headlines and photos in this report may have been modified by Business Standard staff. The rest of the content is auto-generated from syndicated feeds.)

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