Health
Innovative strategy to target blood proteins for treatment of Alzheimer’s disease — ScienceDaily
An international research team led by Professor Nancy IP, Morningside Professor of Life Sciences at The Hong Kong University of Science and Technology (HKUST) and Director of the Hong Kong Center for Neurodegenerative Diseases (HKCeND), has a key role in the pathogenesis of Alzheimer’s disease (AD) fulfill. Their findings reveal innovative strategies to reduce the risk of developing Alzheimer’s disease and improve the condition of people with Alzheimer’s disease.
Affected by more than 50 million people worldwide, AD is an irreversible condition for which there is currently no effective treatment. This is mainly because the disease mechanisms are complex and largely unknown, and there are few effective targets available for drug development. Researchers have previously observed that impaired clearance of toxic amyloid-beta (Aβ) peptides in the brains of AD patients by immune cells (microglia) causes cellular dysfunction, leading to memory loss and cognitive impairment. However, the reasons behind this disorder are still poorly understood.
Here, the team discovered a blood protein, soluble ST2 (sST2), that plays a key role in interfering with Aβ clearance by microglia. The team found that sST2 levels in the blood and brain increase with age, which disrupts the activity of the cytokine interleukin-33 (IL-33), reduces microglial clearance of Aβ, and increases Aβ deposition. shown to increase. Indeed, the team had previously discovered a beneficial activity of IL-33 on microglial clearance of her Aβ in the brain. Interestingly, they further found that lowering sST2 levels had a protective effect against the development of AD and improved AD-related pathology in diseased individuals.
The research team also found that sST2 levels are regulated by genetic factors. An individual with a genetic variant called ‘rs1921622’ has relatively low levels of her sST2 protein in blood and brain even with age and is less likely to develop AD. This is especially pronounced in a woman with her APOE4 gene, the strongest genetic risk factor for AD. Postmortem brain studies by the team revealed that carriers of this protective gene variant had AD characterized by reduced Aβ plaque deposition, reflecting enhanced Aβ clearance by microglia in the brain. The associated symptoms were greatly relieved.
Taken together, these important findings open up new possibilities for AD therapy primarily aimed at reducing sST2 levels. This innovative strategy only requires the manipulation of proteins in the blood, thus offering a simpler and safer approach compared to other therapeutic strategies that target the brain. It offers hope for a high-risk group, such as APOE4 carriers of AD, who are at higher risk of developing AD and tend to have more severe symptoms after onset, accounting for 25% to 50% of all AD patients.
“While this exciting study has furthered our understanding of Alzheimer’s disease and identified excellent drug targets for developing therapeutics, the importance of precision medicine in tackling this complex multifactorial disease was also revealed,” said Professor Ip. “The next step is to develop clinical interventions that target sST2 and determine their feasibility as effective AD prevention and treatment, especially for female APOE4 carriers who are at high risk of developing AD. .”
This work was carried out with support from the Hong Kong Special Administrative Region Government’s InnoHK scheme, in collaboration with researchers from University College London and Stanford University, and clinicians from Prince of Wales Hospital, University of Melbourne, and Edith Cowan University. rice field.The results were recently published in a journal natural aginghas also been featured and actively discussed on various academic exchange platforms focused on AD research, such as Alzforum.
Story source:
material provided by Hong Kong University of Science and Technology. Note: Content may be edited for style and length.
|
Sources 2/ https://www.sciencedaily.com/releases/2022/08/220824102501.htm The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
