Combination ‘polypill’ lowers risk of major cardiovascular events, study finds

Research authors led by Dr. Valentin FusterDirector of the Mount Sinai Heart in New York City and General Director of the Spanish National Cardiovascular Research Center .Ages 75 or 65 years or older with at least one risk factor, such as diabetes or mild or moderate renal impairment.

Half of the patients received polypills containing aspirin, ramipril, and atorvastatin, and the rest received their usual standard of care. The patient was followed for a median of 3 years.

The researchers found 48 cardiovascular deaths in the polypill group and 71 in the usual care group. This means that the relative risk of cardiovascular death in patients taking the polypill was reduced by 33%. The polypill also favored other measures studied in the trial, such as stroke and myocardial infarction.

The polypill and the trial came after 15 years of research, Fester said. He and his colleagues determined that one of the major problems in medicine, especially in the cardiovascular field, especially in heart attack patients, is non-compliance with the medications they are meant to take.

of American Heart Association After having a heart attack, I list taking prescribed medications as one of the first things people can do to prevent another heart attack.

“There seems to be a very good tool that’s a simple polypill and is actually much better,” said Fuster. “Probably most of that is due to increased adherence. It’s a simple drug, it gives good results, and it’s as good or better than aspirin in the past.”

He said it was notable that the two curves for those who took the polypill and those who received standard care separated from the beginning and continued to separate as the years went on. The result will be “even more impressive”.

Faster said the polypill could have a “very significant” impact on the general public.

according to U.S. Centers for Disease Control and Prevention, in the US someone has a heart attack every 40 seconds. About 805,000 heart attacks occur in this country each year, 200,000 of which occur in people who have already had a heart attack.

This study has some limitations. For example, the trial was not conducted in a blinded fashion and all patients were enrolled before her Covid-19 pandemic.

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