Health
Study provides potential diagnostic and therapeutic tool for fatty liver-induced diabetes
Non-alcoholic fatty liver disease and type 2 diabetes are increasing rapidly in India.
The researchers analyzed blood samples from fat-fed mice and human NAFLD patients.Representative photo: India Science Wire
A new study by a team of researchers from several Indian institutions has elucidated a biochemical link between fatty liver disease and type 2 diabetes (T2DM). This understanding is expected to help develop new tools for the diagnosis and treatment of fatty liver-induced diabetes.
We assume that this study is important as the prevalence of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes is rapidly increasing in India. A recent study found that 40% of Indian adults suffer from her NAFLD and about 50 million Indian adults have both her NAFLD and type 2 diabetes.
The research team consisted of researchers from the Indian Institute of Technology Mandi, CSIR-Indian Chemistry and Biology Institute, Kolkata, and the Institute of Graduate Medical Education (SSKM Hospital), Kolkata. They published a report on their findings in the scientific journal Diabetes.
Explaining the importance of their study, the researchers pointed out that it is a known fact that NAFLD affects the function of pancreatic beta cells to release insulin. However, the mechanism was not fully understood. New research has filled the gap.
The researchers analyzed blood samples from fat-fed mice and human NAFLD patients. Both sets of serum samples were found to contain high amounts of a calcium-binding protein called S100A6, and further studies showed that it inhibited insulin secretion. Further studies have shown that protein depletion improves insulin secretion and glycemic regulation in mice.
The researchers said the study is important in many ways. From a diagnostic perspective, we show that elevated S100A6 protein levels in her blood may serve as a biomarker to identify her risk of type 2 diabetes in NAFLD patients.
The team includes Dr. Prosenjit Mondal, Associate Professor, Department of Biological Sciences and Biotechnology, IIT Mandi, and his academics Surbhi Dogra, Priya Rawat, Dr P Vineeth Daniel, CSIR-Indian Institute of Chemical Biology, Dr Partha Chakrabarti, Kolkata, and his colleagues. was made up of colleagues from Dr. Debajyoti Das, Dr. Sujay K Maity, Dr. Avishek Paul, Dr. Kausik Das and Dr. Souveek Mitra from IPGMER in Kolkata and his SSKM Hospital. (India Science Wire)
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