Insulin Pills ‘Breakthrough’ Diabetes ‘Game Changer’

Those who hate needles, rejoice.

Canadian researchers are developing oral insulin tablets to replace the need for daily injections for patients in need. According to Eurekalert.org.

A “breakthrough” at the University of British Columbia has been successfully tested in rats. Rats absorbed insulin from the oral tablet as well as when injected.

“These exciting results demonstrate that we are on the right track in developing insulin formulations that eliminate the need to inject before each meal and improve quality of life and mental health. Over 9 million people with type 1 diabetes Principal Investigator and Professor Dr. Anubav Pratap Singh said:

Pratap-Singh added that oral dosage forms can also prove significantly more cost-effective than traditional injections.

Unlike most non-injectable forms of insulin, this tablet dissolves between the patient’s gums and cheek rather than being swallowed.

And while test results confirm that nearly 100% of insulin tablets go straight to the liver, most previous attempts at drinking insulin have been retained in the stomach. “Similar to fast-acting insulin injections, our oral delivery his tablets he absorbs after 30 minutes and lasts about 2-4 hours,” he added.

“Two hours after parturition, there was no insulin in the stomachs of the rats examined. It’s all in the liver, which is an ideal target for insulin and exactly what we wanted to see. ‘, repeated Yigong Guo, lead author of the pill study.

In addition to seamless biological delivery and future cost savings, Pratap-Singh said the breakthrough could also have environmental benefits.

“More than 300,000 Canadians must inject insulin multiple times a day,” said Pratap-Singh. “That’s a lot of environmental waste from the plastic of needles and syringes that aren’t recycled and can end up in landfills, but that’s not a problem with oral tablets.”

He said it would take more time, but he needs funding and additional collaborators before human trials can begin.

For Pratap-Singh, his quest to make life easier for diabetics pays homage to his father, a patient who has been injecting insulin three to four times a day for the past 15 years.

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