Health
Two antibodies identified in Israel may fight all known Covid strains: study
Israeli scientists have isolated two antibodies from the immune system of recovered COVID-19 patients.This antibody has the potential to neutralize all known SARS-CoV-2 strains, including Omicron, with up to 95% efficiency
Israeli scientists have isolated two antibodies from the immune system of recovered COVID-19 patients.This antibody has the potential to neutralize all known SARS-CoV-2 strains, including Omicron, with up to 95% efficiency
The Tel Aviv University team said targeted therapy with antibodies and their delivery in high concentrations could serve as an effective alternative to vaccines, especially for at-risk populations and those with weakened immune systems. pointed out.
The use of antibody therapy could eliminate the need for repeated booster shots across the population each time a new variant emerges, the researchers said.
of studyrecently published in the journal communication biologyis a continuation of preliminary research conducted in October 2020, at the height of the COVID-19 crisis.
Also Read: Bharat Biotech’s Intranasal COVID Vaccine Receives Emergency Use Authorization
At that time, the team sequenced all B immune system cells from the blood of people who had recovered from the original COVID-19 strain in Israel and isolated nine antibodies produced by the patients.
Researchers have now found that some of these antibodies are highly effective in neutralizing the novel coronavirus subspecies Delta and Omicron.
“Previous studies have shown that different antibodies formed in response to infection with the original virus are directed against different parts of the virus,” said study co-leader Natalia Freund said.
“The most effective antibodies are those that bind to the viral ‘spike’ protein, in the same place that the spike binds to the cellular receptor ACE2,” Freund said.
of SARS-CoV-2 virus It uses spike proteins to infect and enter cells.
Also Read: High Cholesterol, Weight and Loss of Fitness May Signal Prolonged COVID: Lancet Study
In the current study, the researchers found that two other antibodies, TAU-1109 and TAU-2310, that bind to the viral spike protein in a region distinct from that where most antibodies were previously concentrated, were indeed It has proven to be highly effective in neutralizing viruses. Subspecies of Delta and Omicron.
“According to our findings, the efficacy of the first antibody, TAU-1109, is 92% in neutralizing the Omicron strain and 90% in neutralizing the Delta strain.”
“The secondary antibody, TAU-2310, neutralizes the omicron mutant with 84% efficacy and the delta mutant with 97% efficacy,” the scientist said. According to Freund, the surprising efficacy of these antibodies may be related to viral evolution.
Also read: Low testosterone levels may increase risk of COVID-19 hospitalization in men: study
The researchers noted that the infectivity of the SARS-CoV-2 virus increased with each mutant. This is because the amino acid sequence of the part of the spike protein that binds to the ACE2 receptor changes each time.
This made the virus more infectious and at the same time evaded the natural antibodies produced after vaccination.
In contrast, the antibodies TAU-1109 and TAU-2310 do not bind to the ACE2 receptor binding site, but to a different region of the spike protein, the researchers said. This region, they said, is the region of the viral spike protein that for some reason does not undergo much mutation, so the new antibodies are effective at neutralizing more virus variants. .
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