Health
Persistent pulmonary insufficiency seen in children with COVID
Low-field MRI showed persistent lung dysfunction in children and adolescents who had recovered from SARS-CoV-2 infection or had long-term COVID, a small study showed.
and Prospective clinical trial54 children and adolescents previously infected with SARS-CoV-2 (29 recovered and 25 with long-term COVID-19 infection) were compared with 9 healthy children using low-field MRI. compared to controls.
The ventilated and perfused lung parenchyma (V/Q match, a measure of air and blood flow to the lungs) was 81% in healthy controls, but only 62% (P.=0.006) recovery group and 60% (P.=0.003) Reported by Ferdinand Knieling, MD and colleagues at Erlangen University Hospital, Germany, in the Long-Term COVID Group Radiology.
Compared to uninfected healthy controls, V/Q match was lower in post-COVID participants infected within the past 180 days (63%, P.=0.03), 180–360 days (63%, P.=0.03), or over 360 days (41%, P.<0.001).
“The lung dysfunction observed in our study is an unexpected finding because children develop robust, cross-reactive and sustained immune responses following SARS-CoV-2 infection,” Knieling and colleagues said. I am writing.
The researchers note that capturing these images adds important information to the literature that confirms that children are not immune to lung dysfunction after COVID-19 infection.
“While our study suggests that COVID-19 infection and sequelae are less severe in younger patients, in contrast to studies that are largely based on survey or self-reported outcomes, our study does not support broad functional It shows that pulmonary changes are indeed present in children and adolescents,” they observed.
Unique to this study, researchers used low-field MRI. This is a technique that has demonstrated lasting damage to lung tissue in adult patients after COVID-19. With a field strength of 0.55 Tesla, the device has very quiet operating noise and low energy absorption in tissue, allowing it to image a wide range of pediatric populations without sedation.
“This study was conceived at a time when evidence of long-term or post-COVID cases in adults was mounting,” Knieling said in a statement. It was also when parents began asking about links to previous infections.”
Determining the prevalence of post-COVID childhood lung disease is difficult, owing to inconsistent, predominantly symptom-based long-term COVID definitions and limited coverage in children. , the researchers note, is getting more complicated.
The average age of participants with COVID-19 after the acute phase was 12 years. The average age of the controls was 10. Twenty-five long-term COVID participants met World Health Organization criteria for symptoms lasting at least 12 weeks.All but one had been vaccinated.
No COVID-19 group required hospitalization during the primary infection period. The median interval from a positive SARS-CoV-2 RT-PCR test to study entry was 222 days. Morphological abnormalities were identified in one participant who recovered.
This study did not compare findings with other reference standards. Additionally, in this study, free breathing was used at all intervals, viable in his 93% of post-acute COVID participants aged 5 years or older.
The study also lacked long-term data, and the number of healthy controls was small. admits.
“Follow-up trials have already begun and we are trying to understand how the findings change over time,” Knieling said. “Furthermore, we will look closely at other organs to see how this correlates with our findings.”
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Disclosure
This work was funded by the Bavarian Ministry of Science and Art.
A researcher revealed a relationship with Siemens Healthcare GmbH. No other conflicts of interest were disclosed.
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