New COVID-like virus found in bats could resist vaccines and spread to humans

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WSU researchers have found that a salvecovirus found in Russian magnolia bats is capable of infecting humans and is resistant to antibodies in people vaccinated against SARS‑CoV‑2.

newly discovered Viruses similar to the virus that causes COVID-19 It was discovered in Russian bats and can infect humans, according to Washington State University researchers.

According to the WSU, a team led by researchers at the Paul G. Allen School of Global Health found that a bat virus spike protein named Khosta-2 infects human cells and is resistant to both monoclonal antibodies and people’s sera. I discovered that I was vaccinated against COVID-19.

Khosta-2 and SARS-CoV-2, the virus that causes COVID-19, belong to the same subcategory of coronaviruses called sarvecoviruses.

“Our research further shows that [viruses] Even in places like western Russia where the Khosta-2 virus was found, its circulation in wildlife outside Asia poses a threat to global health and the ongoing vaccine campaign against SARS-CoV-2. said WSU virologist and author Michael Letko. of a study published in the journal PLoS Pathogens.

Letko said the discovery of Khosta-2 highlights the need for a universal vaccine to protect against not only known variants of SARS-CoV-2, but this subcategory of coronaviruses in general. rice field.

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“There are groups currently trying to come up with vaccines that not only prevent the next variant of SARS-2, but actually protect us from sarvecoviruses in general.” It’s designed for the specific viruses known to infect human cells, or those that seem to pose the greatest risk of infecting us, but that’s an ever-changing list. against Becovirus.”

Hundreds of sarvecoviruses have been found in recent years, mostly in Asian bats, researchers say, most of which are incapable of infecting human cells. The Khosta-1 and Khosta-2 viruses he discovered in Russian bats in late 2020 did not initially appear to pose a threat to humans.

read more: Should I get the new COVID booster and flu shot at the same time? Your question answered

“Genetically, these strange Russian viruses were similar to some of the other viruses found elsewhere in the world, but they didn’t look like SARS-CoV-2, so they didn’t look like SARS-CoV-2. No one thought it wouldn’t be exciting,” says Letko. He said. “But when I looked further into them, I was really surprised to find that they can infect human cells. This gives me an idea of ​​where these viruses, viruses, come from and what regions are involved. My understanding of the has changed a bit.”

Letko and other WSU virologists studied the virus further and determined that Khosta-1 poses a low risk to humans, while Khosta-2 displayed “some troubling features.”

Similar to SARS-CoV-2, Khosta-2 can use its spike protein to infect cells by attaching to receptor proteins found throughout human cells.

read more: 4.4 million Americans received new Omicron-targeted COVID-19 boosters, CDC says

Using sera from people vaccinated against COVID-19, the team confirmed that current vaccines do not neutralize Khosta-2. They also tested sera from people infected with the Omicron variant, but those antibodies were also ineffective.

Fortunately, the new virus lacks some of the genes thought to be responsible for spreading infections in humans, says Letko. However, there is a risk that Khosta-2 will recombine with his second virus, like his SARS-CoV-2.

“Seeing that SARS-2 has this ability to bleed from humans into wildlife is another virus like Khosta-2 waiting in animals with these traits that we really don’t want them to have.” It’s a scenario where you keep rolling the dice and combining them to create a potentially dangerous virus,” Letko said.

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