Connect with us


Study characterizes immunological features of SARS-CoV-2 infection in children




A recent study conducted by a team of Italian scientists found that the clinical severity of coronavirus disease 2019 (COVID-19) in children was induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. demonstrated to depend on the dynamics of the immune response. .

Study: The immunological profile of SARS-CoV-2 infection in children is related to clinical severity and age. Image Credit: CROCOTHERY/Shutterstock
study: The immunological profile of SARS-CoV-2 infection in children is related to clinical severity and age. Image Credit: CROCOTHERY/Shutterstock

This research is currently research plaza* Preprint server considering publishing on scientific report.


SARS-CoV-2, the causative agent of COVID-19, has caused less severe infections in children and adolescents throughout the pandemic. However, clinical severity may also be observed in some cases, such as pediatric systemic polyinflammatory syndrome (MIS-C). This condition is characterized by an abnormal inflammatory response.

The reasons behind the observed differences in clinical severity between children and adults are not fully understood. However, patterns of social interaction viral loadand age-related immune response dynamics make children less susceptible to SARS-CoV-2 infection.

In the current study, scientists evaluated the correlation between immune responses induced by SARS-CoV-2 and COVID-19 severity in children. In a subset of children with severe infection, we characterize immune response dynamics with cardiovascular manifestations.

Study population

This study included a total of 18 children hospitalized with SARS-CoV-2 infection. The immunological profile of infected children was compared with that of 13 healthy children (controls).

Patients were classified based on clinical severity and age. Moderate and severe infections were found in his 56% and his 44% of patients. Her average length of stay was 12 days, and her only child was admitted to the intensive care unit (ICU).

Patients with moderate infections had upper or lower respiratory tract infections without organ dysfunction. In contrast, severely infected patients experienced multiple organ failure or required supplemental oxygen. Cardiovascular involvement was documented in 7 children.

Dynamics of antibody responses in children infected with SARS-CoV-2

binding and Neutralizing antibody Virus against SARS-CoV-2 was detected in 78% of patients.

In addition to clinical severity, age-related differences in antibody responses in hospitalized children were assessed. Based on age, they were classified as infants, children, and adolescents.

Significantly higher levels of anti-spike receptor binding domain (RBD) IgG antibodies were detected in severely infected children than in moderately infected children. Significantly higher levels of anti-RBD IgM antibodies were detected in moderately infected adolescents than in heavily infected infants. Regarding neutralizing antibodies, significantly higher values ​​were detected in severely ill children than in severely ill children.

Dynamics of inflammatory response

Patients with severe infection had significantly higher levels of circulating cytokines and chemokines compared with those with moderate infection. The highest levels of cytokines and chemokines were detected in infants with severe infections.

A comparison of inflammatory and antibody responses revealed a negative correlation between antibody and cytokine/chemokine levels in infants and children with severe infections and cardiovascular disease. In particular, anti-SARS-CoV-2 binding antibodies negatively correlated with interleukin-2 (IL-2).

A strong correlation was observed between selected cytokines and chemokines among infants, children and adolescents with moderate infections. Considering virus-specific binding antibodies, a negative correlation with IL-12 levels was observed.

Only weak correlations between antibodies and inflammatory responses were observed in children and adolescents with moderate infection and very low cytokine/chemokine levels. Virus-specific binding antibodies negatively correlated with IL-8, IL-5, and monocyte chemoattractant protein-1. Notably, the circulating cytokine/chemokine profiles of these patients significantly overlapped with those of healthy children.

Compared with healthy children, SARS-CoV-2-infected children had significantly increased production of SARS-CoV-2-stimulated cytokines and chemokines, leading to T lymphocyte activation and migration-specific proteins. It was observed that the levels of

Significance of research

This study provides an overview of antibody and inflammatory responses in hospitalized infants, children and adolescents with moderate or severe SARS-CoV-2 infection. Overall, this study reveals that the dynamics of virus-induced immune responses are directly correlated with disease severity and partially correlated with age.

*Important Notices

Research Square publishes non-peer-reviewed, preliminary scientific reports and should not be taken as conclusive, to guide clinical practice/health-related actions, or to be treated as established information. .




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]