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Global Study Finds COVID-19 Vaccination May Affect Menstrual Cycle

Global Study Finds COVID-19 Vaccination May Affect Menstrual Cycle

 


A woman receives an injection of the COVID-19 vaccine from a doctor.

According to a study led by OHSU clinical scientist Alison Edelman, changes in menstrual cycles after COVID-19 vaccination include increased or decreased menstrual cycles, missing cycles, increased and decreased menstrual flow, and intermenstrual spots. And so on. (Getty Images)

A new international study finds that some people experience slight temporary changes in the length of their monthly menstrual cycles after being vaccinated against COVID-19.

The study was led by clinicians and scientists at Oregon Health and Science University Alison EdelmanMD, MPHand was published today in the journal BMJMore medicinebased on previous work by the same research team that first identified a link between the COVID-19 vaccine and menstrual cycle changes.

    Alison Edelman MD MPH stands on the terrace outside the OHSU Women's Health Center.

Alison Edelman, MD, MPH (OHSU)

their initial investigation Contains data from individuals in the United States. This recent study was extended to analyze data from an international cohort representing a larger and more geographically diverse population receiving a wider variety of vaccines. Additionally, researchers were able to look at the menstrual cycle after vaccination to see how long it would take for changes to resolve.

“It’s troubling given that menstruation is terribly understudied and an important indicator of fertility and overall health,” said the study’s principal investigator, professor of obstetrics and gynecology, Edelman, director of complex family planning at the OHSU School of Medicine, said. “Our findings using this large dataset are very consistent with previous research. Some people experience slightly longer cycles on the COVID-19 vaccine, but most We’ll be back to normal soon.”

“But more importantly, our findings further validate what so many people have reported experiencing, helping medical professionals provide better care and clinical recommendations to their patients. I hope I can.”

Various menstrual cycle changes have been reported after COVID-19 vaccination. These include lengthened and shortened menstrual cycles, missing cycles, increased and decreased menstrual flow, and intermenstrual spots. However, clinical trials of the vaccine have not collected results related to the menstrual cycle, leaving major gaps in knowledge about these issues, prompting Edelman and team to look more closely at what is commonly reported. I was.

Data from this study includes over 250,000 menstrual cycles recorded by approximately 20,000 individuals using a menstrual cycle tracking application. natural cyclethe participants gave the researchers permission to use the anonymized data.

The findings were consistent with those seen in the US cohort. The individual who received her two doses of her COVID-19 vaccine in one menstrual cycle had an average increase of 3.7 days in cycle length compared to the unvaccinated group. On average, vaccinated people experienced an increase of less than 1 day with each cycle of vaccination: an increase of 0.71 days after the first dose and 0.56 days after the second dose.

Individuals experienced changes in cycle length whether they were vaccinated or not, but the proportion of vaccinated individuals who were vaccinated compared to those who were not vaccinated (5%) experienced a change of 8 days. Cycle length increased over time (13.5%). Furthermore, the changes in cycle length appeared similar across different vaccine types, raising concerns about new vaccine technology among people. Edelman said it gives people peace of mind.

“Changes in routine bodily functions can be startling and cause fear and anxiety,” Edelman said. I would like to emphasize that it resolves with cycles. I hope this knowledge clarifies what people can expect after vaccination.”

Those who notice prolonged menstrual changes are advised to seek guidance from their clinician.

These findings will enable clinicians to better advise individuals on what to expect with COVID-19 vaccination and how to make informed decisions about vaccination. However, researchers say more research is needed for other changes in the menstrual cycle, such as unexpected vaginal bleeding, menstrual flow, and pain. The researchers believe these changes are likely due to transient vaccine-associated activation of immune responses, but a full understanding of the biological mechanisms is required. , further research is needed.

This study was funded by the National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD) and NIH Office of Women’s Health Research (NIH NICHD089957 Supplement).

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reference

Edelman A., et al. Association between menstrual cycle length and COVID-19 vaccination: a global cohort. British Journal of Medicine. 2022 (BMJMED2022;0.doi:10.1136/bmjmed-2022-000297)

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2/ https://news.ohsu.edu/2022/09/27/global-study-finds-covid-19-vaccination-can-affect-menstrual-cycle

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