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Frozen embryos associated with hypertension risk during pregnancy




September 27, 2022 Pregnancies with frozen embryos from in vitro fertilization (IVF) appear to be associated with a higher risk of hypertension-related complications compared with unfrozen embryos and natural pregnancies. new research was announced in high blood pressure.

After a frozen embryo transfer, you may have a 74% higher risk of developing hypertensive disease compared to a natural pregnancy. The risks after fresh embryo transfer appear to be the same as for natural pregnancies.

“Frozen embryo transfers are now becoming more and more common around the world. In the last few years, some doctors have begun skipping fresh embryo transfers and routinely freezing all embryos in their clinical practice. The so-called “freeze everything” approach. Dr Sindor Petersen, lead study author and Fellow of the Norwegian University of Science and Technology, said: in a statement.

“Our results highlight the need to carefully consider all benefits and potential risks before freezing all embryos as a routine part of clinical practice,” he said. “It is important to have a comprehensive and individualized discussion between physicians and patients about the benefits and risks of fresh versus frozen embryo transfers.”

High blood pressure during pregnancy can be a sign of pre-eclampsia, a serious pregnancy complication that can be life-threatening for the mother and baby. to the American Heart AssociationApproximately 1 in 25 pregnancies in the United States will result in pre-eclampsia. Most mothers give birth to healthy babies and recover completely from pre-eclampsia, but in some cases the condition can cause liver and kidney damage, increasing the risk of future heart problems. .

Petersen et al. analyzed medical birth register data for more than 4.5 million pregnancies over 30 years in Denmark, Norway, and Sweden. The registry contained approximately 4.4 million pregnancies from spontaneous pregnancies, 78,300 pregnancies from fresh embryo transfer, and 18,037 pregnancies from frozen embryo transfer.

The researchers compared 33,000 pregnancies among mothers who had both IVF pregnancies and spontaneous pregnancies, called sibling comparisons, and found that this possible reason for hypertensive disorders was related to parental factors or IVF. I checked to see if there was

The research team found that the prevalence of hypertensive disease during pregnancy was 7.4% after frozen embryo transfer, 5.9% after fresh embryo transfer, and 4.3% after natural conception.

Early pregnancies were also more common with embryo transfer. Approximately 8.1% of pregnancies were preterm after fresh embryo transfer, followed by frozen embryo transfer in 6.6% and spontaneous pregnancies in 5%.

The findings are “consistent with previous population-level studies” showing an increased risk of hypertensive disease during pregnancy after frozen embryo transfer, the study authors said.

For example, a study done last year in France found that the risk of preeclampsia and high blood pressure was higher in pregnancies using frozen-thawed embryos. Risk was higher.

“There is one thing that is not clear. Is it due to the actual procedure of freezing the embryos or the protocol used? I believe it’s a medication protocol, not an IVF procedure,” says Aimee Eyvazzadeh, M.D., a reproductive endocrinologist in San Francisco. told CNN.

The uterus can be prepared for implantation in a number of ways, she explained. One method involves the corpus luteum, which produces progesterone, a hormone needed during pregnancy. dependent on drugs for Some studies have found that the absence of the corpus luteum may increase the risk of pre-eclampsia, especially with cryopreservation.

“Everyone caring for a pregnant person after in vitro fertilization should pay close attention to this research,” Eyvazzadeh said. A growing body of research indicates that IVF after frozen embryo transfer may increase the risk of pre-eclampsia.”




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