Health
This robotic pill clears the gut of mucus and delivers medicine
Mucus-wicking robotic pills may offer a new way to deliver drugs.
The multivitamin-sized device houses a motor and a drug cargo compartment containing drugs that are typically injected or given intravenously, such as insulin and some antibiotics. If people could take such drugs orally, which could potentially avoid daily injections and hospital stays, it would be a “big game changer,” says MIT biomedical engineer Shriya Srinivasan.
However, drugs that enter the body through the mouth face a difficult road. They encounter raging stomach acid, blistering digestive enzymes, and mucus-like mucus in the gut. Goo traps drug particles, preventing them from entering the bloodstream.
A new device called RoboCap solves this problem. The tablets use surface grooves, studs, and torpedo-inspired fins to scrape off intestinal mucus like tiny brushes that rotate inside the bottle. In experiments with pigs, RoboCap passes through the mucus lining the small intestineen route to depositing insulin or the IV antibiotic vancomycin, Srinivasan and colleagues report Sept. 28. science robotics. After stirring for approximately 35 minutes, the tablet continued to move through the intestine and was eventually excreted.
RoboCap is the latest pill-like gadget made to be swallowed. In 2019, some of the same researchers who developed RoboCap debuted another device. insert a needle into the stomach and inject the medicine (SN: February 7, 2019). That pea-sized syringe wasn’t designed to work in the small intestine, where some drugs are best absorbed. RoboCap could also potentially deliver larger drug payloads, he said, Srinivasan.
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