Health
New drug seeks ‘true revenge’ against COVID by turning virus against itself
A neuroscientist at a renowned US research institute has developed an COVID treatment he calls “true revenge” that weaponizes the virus against itself.
The treatment, called NMT5, was created by Dr. Stuart Lipton, founder of the Scripps Research Institute’s Center for Neurodegenerative New Drugs, and a team of scientists. It is a derivative of memantine, the Alzheimer’s drug Lipton, developed in the 1990s, derived from a drug used in people who had the flu in the 1960s.
Currently, NMT5, a COVID antiviral drug, if approved by the U.S. Food and Drug Administration, could be taken orally by infected people much like Paxlovid, a common pill taken at home by people diagnosed with the virus. It will be.
But unlike Paxlovid, which prevents COVID from replicating inside the body of an infected person, NMT5 modifies the virus, acquiring a “warhead” that temporarily alters the cells that COVID normally attaches to and invades, allowing the virus to prevent infection.
Because of its different approach to attacking the virus, NMT5 is thought to prevent the spread of infection to others. According to the study, people infected with the novel coronavirus and taking new drugs are expected to spread a virus that destroys itself. That is, it should not be able to infect new hosts.
Lipton, who is also a professor of neuroscience and neurology at the University of San Diego, said this is a feat that no other COVID vaccine or treatment has yet accomplished. School of Medicine and Yale University School of Medicine.
a peer-reviewed research Published September 29 by Lipton and his team. nature chemical biology Promising results have been obtained by using the drug in Syrian golden hamsters, which are highly susceptible to COVID and are considered the gold standard when testing potential treatments.
The study also found that in hamsters, the drug “virtually eliminated” the large pulmonary hemorrhages that are often seen at autopsies in COVID-dead people. It also significantly reduced the inflammatory response in ingested hamsters compared to uningested hamsters.
Furthermore, NMT5 was found to be highly effective against COVID variants alpha, beta, gamma, delta, and omicron. It reduced the virus’ ability to replicate within its host and infect others by up to 95%, the study said.
Yet another bonus: In addition to being taken in tablet form, the drug can also be inhaled.
NMT5 is a combination of two FDA-approved drugs, memantine and nitroglycerin, so it’s likely safe, Lipton said, but it still needs to be reviewed by the FDA. He hopes that human experiments will begin in the next few months, or a year at most. If FDA approval is obtained, the drug will enter the market shortly thereafter.
He has no illusions that the drug will end the pandemic, even in the best-case scenario. Combined with improved boosters, you can finally tame the raging virus.
“The beauty of this new drug is that it’s completely new,” Lipton said of the drug, which was developed to treat influenza before it turned into a drug for Alzheimer’s disease.
“We took antivirals, made it better for the brain, then better for the virus. What’s the cooler story than that?
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Sources 2/ https://fortune.com/well/2022/10/03/new-covid-drug-antiviral-turns-virus-against-itself-coronavirus-prevent-spread-nmt5-scripps-paxlovid/ The mention sources can contact us to remove/changing this article |
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