Antidepressants during pregnancy do not affect children’s neurodevelopment, study finds

Antidepressant use during pregnancy is not associated with an increased risk of neurodevelopmental disorders in children. JAMA Internal Medicine.

Elizabeth A. Suarez, M.D., Ph.D., of Brigham and Women’s Hospital in Boston and Harvard Medical School and colleagues investigated the association with antidepressant use. pregnancy Child neurodevelopmental outcomes using data from cohorts of publicly and privately insured pregnant individuals and their children. A total of 1.93 million pregnancies were recorded in the Medicaid Analytic eXtract and 1.25 million pregnancies were recorded in the IBM MarketScan Research Database. Children were followed for up to 14 years from birth. Data included 145,702 pregnancies exposed to antidepressants and 3,032,745 pregnancies not exposed.

The researchers found that crude results suggest up to a two-fold increase in the risk of neurodevelopmental outcomes associated with exposure to antidepressants. However, no association was observed in fully adjusted analyses. When comparing antidepressant-exposed and unexposed siblings, the hazard ratios (95% CI) were 0.97 (0.88 to 1.06), 0.86 (0.60 to 1.23), 0.94 (0.81 to 1.08), 0.77 ( 0.42 to 1.39), 1.01 (0.88 to 1.16), 0.79 (0.54 to 1.17), 1.00 (0.45 to 2.22), and 0.95 (0.80 to 1.12) any neurodevelopmental disorder, autism spectrum disorderattention deficit/hyperactivity disorderspecific learning disabilities, developmental speech/language disorders, developmental coordination disorderintellectual disability, and behavioral disability.

“Exposure to antidepressants during pregnancy may be an important marker for early childhood screening and intervention, neurodevelopmental disorders” writes the author.

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Exposure to antipsychotics in utero may not increase risk of neurodevelopmental disorders

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For more information:
Elizabeth A. Suarez et al., Association of antidepressant use during pregnancy with risk of neurodevelopmental disorders in children, JAMA Internal Medicine (2022). DOI: 10.1001/jamainternmed.2022.4268

Several authors revealed financial ties to the biopharmaceutical industry.

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