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Understanding Long-Term Symptoms of COVID-19 and Accelerating Recovery – NIH Director’s Blog

Understanding Long-Term Symptoms of COVID-19 and Accelerating Recovery – NIH Director’s Blog

 


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RECOVER: Researching COVID to enhance recovery.Initiative funded by the National Institutes of Health

We are in the third year of the COVID-19 pandemic, with most restrictions being lifted around the world and society trying to return to ‘normal’. But for many people, perhaps millions around the world, there is still no return to normality.

They still carry the long-term effects of COVID-19 infection, known as acute sequelae of SARS-CoV-2 infection (PASC). long covidThese people continue to experience debilitating fatigue, shortness of breath, pain, difficulty sleeping, increased heart rate, exercise intolerance, gastrointestinal and other symptoms, as well as cognitive problems that make it difficult to perform at work or school. .

This is a public health question that desperately needs an answer. Research is essential to address the many puzzling aspects of the long COVID and guide us toward effective responses that protect the long-term health of our nations.

Over the past two years, NIH’s National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Neurological Disorders and Stroke (NINDS), and several other NIH institutes and the NIH Director’s Office of NIH COVID research to enhance recovery (RECOVER) Initiative, National Research Program to Understand PASC.

This initiative will explore the lingering effects of COVID-19 infection, why new symptoms may occur, and the impact of SARS-CoV-2, the virus that causes COVID-19, on other diseases and conditions. Researching major issues. Answering these basic questions will help determine the underlying biological basis of long COVID. Responses also help identify people at risk for Long COVID and identify treatments to prevent or treat the condition.

The broad research scope of the RECOVER initiative is also unprecedented. Long COVID is so complex and necessary because history shows that similar post-infectious conditions defy definitive explanations and effective treatments. have reported a wide variety of symptoms, making it highly unlikely that a single treatment will work for everyone, highlighting the need to pursue multiple therapeutic strategies.

To fully understand Long COVID, hundreds of RECOVER investigators We are recruiting Over 17,000 adults (including pregnant women) and over 18,000 children participated in the cohort study. Hundreds of registration sites have been set up nationwide. An autopsy study cohort will also provide further insight into how COVID-19 affects organs and tissues in the body.

In addition, researchers will analyze electronic health records from millions of people to understand how long COVID and its symptoms change over time. The RECOVER initiative also utilizes consistent research protocols across all research sites. The protocol has been carefully developed with input from patients and advocates and is designed to enable consistent data collection, improve data sharing, and help accelerate the pace of research.

From the beginning, people suffering from Long COVID have been RECOVER’s partners. Patients and supporters contributed important perspectives and provided valuable input to the master protocol and study design.

RECOVER is now underway, and long-term COVID patients, their caregivers, and community members continue to play an important role in the initiative. The National Community Engagement Group (NCEG) was established to ensure RECOVER meets the needs of all those affected by Long COVID.of RECOVER patient and community engagement strategies It outlines all the approaches RECOVER is using to engage with and collect information from individuals affected by Long COVID.

Recently produced by the NIH 40+ Awards To advance our understanding of the underlying biology and pathology of long COVID. Several important discoveries have already been published by RECOVER scientists.

for example, Recent research It was published in the magazine lancet digital healthRECOVER investigators used machine learning to comb through electronic health records, looking for signals that could predict whether someone was a long-term carrier of COVID. [1]New discoveries, tools, and technologies continue to emerge to help improve our knowledge of the condition. RECOVER Research Review (R3) Seminar Series Provide researchers and partners with a forum to keep them up-to-date on long-term COVID research.

It is important to note that the post-viral state is not a new concept. Many, but not all, symptoms reported with long COVID, including fatigue, post-exercise malaise, chronic musculoskeletal pain, sleep disturbances, postural orthostatic tachycardia (POTS), and cognitive problems Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)).

ME/CFS is a serious disease that develops after infection and leads to severe illness for decades. Like long COVID, ME/CFS is a heterogeneous condition that does not affect everyone equally, and knowledge gained through research on long COVID will help us understand, treat, and treat POTS, ME/CFS, and others. and prevention may also have a positive impact. chronic disease.

Unlike other post-virus conditions, people who experienced Long COVID were all infected with the same virus, albeit with different variants, at the same point in time. This creates a unique opportunity for RECOVER researchers to study the post-viral state in real time.

This opportunity allows scientists to study many people simultaneously while still infected to monitor progression and recovery, and to try to understand why some individuals develop ongoing symptoms. A better understanding of the transition from acute to chronic illness will help us intervene, identify those at risk for the transition, and treat for those who experience symptoms long after the acute infection has healed. may provide opportunities to develop

The RECOVER initiative will soon publish a clinical trial leveraging data from clinicians and patients in whom clusters of symptoms have been identified and targeted for various interventions. These trials will investigate treatments indicated for other conditions besides COVID and novel treatments for long-term COVID.

Through extensive collaboration across the multiple NIH laboratories and offices contributing to the RECOVER effort, we hope that important answers will soon emerge. These responses recognize all the consequences and needs arising from PASC and most importantly help many people to fully recover from her COVID-19. We are grateful to her over 10,000 subjects who have already enrolled in RECOVER. Their contributions and the hard work of his RECOVER investigators bring hope for the future to millions of people suffering from the pandemic.

reference:

[1] Identifying people with long-term COVID in the US: a machine learning approach using N3C dataPuff ER, Garvin AT, Bennett TD, Bhatia A, Brooks IM, Dia RR, Dekermanjian JP, Jolie SE, Khan MG, Kostka K, McMurry JA, Moffitt R, Walden A, Shute CG, Handel MA. N3C Consortium. Lancet digit health. 2022 July;4(7):e532-e541.

Link:

COVID-19 research (NIH (National Institutes of Health)

long covid (NIH (National Institutes of Health)

RECOVER: COVID Research to Accelerate Recovery (NIH (National Institutes of Health)

NIH will build a large research population of tens of thousands nationwide to support research on the long-term effects of COVID-19,” NIH News Release, Sept. 15, 2021.

Message from Director (National Institute of Neurological Disorders and Stroke/NIH)

Note: Dr. Lawrence Tabak, who carries out the duties of the NIH Director, invites the heads of NIH’s Institutes and Centers (ICs) to blog occasionally to highlight some of the interesting science they support and conduct. You have been asked to submit a guest post. This is his 18th in a series of his NIH IC guest posts that will run until his new permanent NIH Director is in place.

Sources

1/ https://Google.com/

2/ https://directorsblog.nih.gov/2022/10/04/understanding-long-term-covid-19-symptoms-and-enhancing-recovery/

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