Connect with us


Researchers Shed Light on How Optimal Uptake of Electrophilic Compounds Like Procyanidins Links Hormesis of Hemodynamic and Metabolic Reactions – ScienceDaily




B-type procyanidins are made up of catechin oligomers and are a class of polyphenols abundant in foods such as cocoa, apples, grape seeds, and red wine. Several studies have established the benefits of these micronutrients in reducing the risk of cardiovascular disease and stroke.B-type procyanidins also successfully control hypertension, dyslipidemia, and impaired glucose tolerance. doing. Studies have demonstrated physiological benefits of consumption on the central nervous system (CNS), namely improved cognitive function. These physiological changes follow a hormesis pattern. Hormesis is a phenomenon in which the effect of a substance is maximal at moderate doses and gradually diminishes at lower or higher doses.

The dose-response relationship for most bioactive compounds follows a monotonic pattern, with higher doses leading to greater responses. However, in some exceptional cases, a U-shaped dose-response curve is seen. This U-shaped curve signifies hormesis. Hormesis is an adaptive response in which low doses of normally harmful compounds induce resistance in the body to high doses. This means that exposure to low-level noxious triggers induces activation of stress tolerance pathways, enhancing their capacity for repair and regeneration. For B-type procyanidins, some in vitro Studies support hormetic effects, but these results have not been substantiated in vivo.

To address this knowledge gap, researchers at Shibaura Institute of Technology (SIT) in Japan, led by Professor Naomi Osakabe of the Department of Life Science and Engineering, reviewed data from an intervention trial supporting hormetic responses to B-type procyanidin intake. Did. In addition, a team consisting of Daiki Fushimi and Yasuyuki Fujii from the Graduate School of Engineering (SIT) of in vivo Experiments to understand possible relationships between B-type procyanidin hormetic responses and CNS neurotransmitter receptor activation. Their article was published online on June 15, 2022 in his 9th volume. The forefront of nutrition science September 7, 2022.

The researchers noted that a single oral administration of optimal doses of cocoa flavanols transiently increased blood pressure and heart rate in rats. I did. Administration of B-type procyanidin monomers and various oligomers produced similar results. According to Professor Osakabe, “These results are consistent with the results of intervention studies after a single intake of foods rich in B-type procyanidins, and support the U-shaped dose-response theory of polyphenols, or hormesis.” I have.”

To see if the sympathetic nervous system (SNS) is involved in the hemodynamic changes induced by B-type procyanidins, the researchers administered an adrenergic blocker to rats. This successfully reduced the transient increase in heart rate caused by optimal doses of cocoa flavanols. This suggests that SNSs, which control the action of adrenergic blockers, are responsible for the hemodynamic and metabolic changes induced by a single oral dose of B-type procyanidins.

The researchers next determined why optimal doses, rather than high doses, are responsible for thermogenic and metabolic responses. They co-administered high doses of cocoa flavanols and yohimbine (an α2 blocker) and noted a temporary but distinct increase in blood pressure in the test animals. Similar observations were made using B-type procyanidin oligomers and yohimbine. “Since α2 blockers are associated with downregulation of the SNS, the decrease in metabolic and thermogenic output seen in our study at high doses of B-type procyanidins is likely due to the activation of α2 autoreceptors,” said Osakabe. It is speculated that it may have induced Inactivation can be induced by high doses of B-type procyanidins. ”

Previous studies have demonstrated a role for the gut-brain axis in regulating hormetic stress-related responses. Activation of the hypothalamic-pituitary-adrenal (HPA) axis by optimal stress has profound effects on memory, cognition, and stress tolerance. In this article, he highlights how HPA activation occurs after a single dose of B-type procyanidins, suggesting that stimulation by oral administration of B-type procyanidins can be a stressor in mammals and cause SNS activation. suggests that there is

Hormesis and the biochemical pathways that trigger it provide protection against a variety of pathological and aging processes, enhance our general health and make us more resilient to future stress. Although the exact relationship with the CNS needs further research, the health benefits of foods rich in B-type procyanidins are undisputed.

Story source:

material provided by Shibaura Institute of Technology. Note: Content may be edited for style and length.




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]