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Virtual library of LSD-like drugs may reveal new antidepressants

Virtual library of LSD-like drugs may reveal new antidepressants

 


Hear what’s new in the world of science with Benjamin Thompson.

In this episode:

00:46 Virtual chemical library reveals potential antidepressants

Certain hallucinogens are of interest to researchers for their promising antidepressant effects. To accelerate the discovery of molecules with useful properties, researchers built a virtual library of her 75 million compounds related to these drugs. This approach yielded two molecules that exhibit antidepressant properties in mice but do not exhibit hallucinogen-like psychedelic effects.

Research papers: Kaplan et al.

Research briefing: Custom library docking of 5-HT2A receptor agonists with antidepressant activity

08:25 Research highlights

An ancient man-made island settlement was the center of activity for society’s elite, and astronomers have discovered perhaps the brightest star ever observed, according to a survey.

Research highlights: Ancient DNA suggests man-made islands were party spots for the elite

Research highlights: Scientists point down ‘Godzilla’, the brightest star known

10:42 Nobel News

Flora Graham of nature briefing Let’s talk about this year’s Nobel Prize winners.

Nature News: Geneticist who uncovered the identity of ancient life wins Nobel Prize in Medicine

Nature News: ‘Eerie’ quantum entanglement experiment wins physics Nobel Prize

Nature News: Chemist who invented revolutionary ‘click’ reaction wins Nobel Prize

Enter Nature’s “Scientist at Work” photo contest.Click here for details

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Sources

1/ https://Google.com/

2/ https://www.nature.com/articles/d41586-022-03185-7

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