Cancer immunotherapy and the Mediterranean diet

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• Researchers say the Mediterranean diet enhanced treatment of melanoma patients with immune checkpoint inhibitors.
• They added that a diet rich in fiber and polyphenols also reduced the risk of side effects from treatment.
• Experts add that a Mediterranean diet is beneficial to the overall health of most people.

Those who love Greek and other Mediterranean foods may be happy to know that what you eat may extend or even save your life.

A new study from the Netherlands and the UK found that a Mediterranean diet can improve the response to immunotherapy in people with advanced melanoma, the most serious type of skin cancer.

This research is today meeting Sponsored by the European Gastroenterological Endoscopy Society. The findings have not yet been published in a peer-reviewed journal.

Their study found that a Mediterranean diet rich in fiber, monounsaturated fatty acids, and polyphenols was associated with improved immunotherapy response rates and progression-free survival in people with advanced melanoma. person reports.

Dr. Laura VolteA nutritionist, doctoral candidate, and author of the study, Healthline tells Healthline that mono- and polyunsaturated fats from olive oil, nuts, and fish, and from vegetables, fruits, and whole grains A Mediterranean diet containing polyphenols and fiber has been associated with significantly improved responses to an immunotherapeutic drug called immune checkpoint inhibitor.

One of the most effective treatments for melanoma so far, inhibitors work by blocking checkpoints in a person’s immune system, causing the body’s T cells to attack the cancer.

Researchers conducting a multicenter study recorded dietary intake in 91 patients with advanced melanoma who were treated with immune checkpoint inhibitors and monitored for progress with regular radiographs.

People who participated in the study were not on a specific diet, but completed a detailed dietary questionnaire before treatment, and researchers assessed their eating habits, Volte explained.

The Mediterranean diet was not only significantly associated with overall response rates, but was also significantly associated with 12-month progression-free survival, researchers report.

Immune checkpoint inhibitors have revolutionized the treatment of many types of advanced cancer. This latest study highlights the importance of dietary assessment when cancer patients start these types of treatments, Bolte said.

Researchers also found that eating whole grains and legumes reduced the likelihood of developing drug-induced immune-related side effects, such as colitis.

In contrast, red meat and processed meat were associated with a higher likelihood of immune-related side effects.

Experts expect diet to play a key role in the success of immunotherapy, and clinical trials are being expanded to investigate outcomes in different types of tumors, including gastrointestinal cancers, says Bolte. said Mr.

The relationship between dietary immune checkpoint inhibitor responses and the gut microbiota opens up a promising and exciting future for enhancing therapeutic responses.

“There are ongoing clinical trials investigating the effects of high-fiber diets, ketogenic diets, and omega-3 supplementation,” says Borte.

She said that as immune checkpoint inhibitor therapy is being expanded to different types of tumors, including gastrointestinal cancers, these studies could reveal therapeutic effects on large groups of cancer patients in the future. I added that it is possible.

Sonya OmeSan Diego business owner and life coach, who was born and raised in Istanbul, Turkey, told Healthline he wasn’t surprised by the findings.

When she returned to Turkey to visit her family, Orme said she felt visibly better. When she returned to the United States, she noticed that her intestinal inflammation had returned to some extent, which she attributed to the food.

Orme says eating olives, olive oil, fish, nuts, vegetables and fruits is healthy, as is adding lemon to your daily diet.

“As soon as I got back to Turkey and started eating it, I noticed a difference. said.

You can really feel the difference when you eat fresh Mediterranean food, said Orme.

“For example, we don’t use dressings that are sold in stores in the United States. For example, they are not healthy. I also think the amount of vegetables consumed daily in a Mediterranean household makes a difference.” We don’t store canned food, we don’t have processed food,” she said.

Historically, nutrition has been somewhat neglected in prospective studies within oncology.

“However, this is changing, and there are many studies underway around the world examining nutrition as an anticancer therapy,” Bolte said.

She added that immune checkpoint inhibitors have improved prognosis in several advanced-stage tumor types.

However, not all cancer patients respond to this treatment.

“Some patients develop drug-induced immune-related side effects such as colitis, an inflammation of the intestine,” she said.

“The question is how can we increase the response to immune checkpoint inhibitors to benefit more patients? opens promising and exciting opportunities for

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