Mediterranean diet improves immunotherapy response and progression-free survival in advanced melanoma

A Mediterranean diet rich in fiber, monounsaturated fatty acids and polyphenols is associated with improved immunotherapy response rates and progression-free survival in patients with advanced melanoma, UEG Week A new study published today in 2022 reveals.

Experts expect diet to play a key role in the success of immunotherapy, and trials are being expanded to investigate outcomes in different types of tumors, including gastrointestinal cancers.

Mediterranean diet with things and things polyunsaturated fat Polyphenols and fiber from olive oil, nuts, fish, vegetables, fruits, and whole grains were significantly associated with improved responses to immunotherapeutic drugs called immune checkpoint inhibitors (ICIs). The highly successful ICI works by blocking checkpoints in the immune system, allowing the body’s own T cells to attack the cancer.

In a new multicenter study by British and Dutch researchers, dietary intake Ninety-one patients with advanced melanoma who were treated with ICI drugs and whose progress was monitored with regular radiographic examinations.

In addition to being significantly associated with overall response rates, the Mediterranean diet was significantly associated with: progression-free survival in 12 months.

Laura Bolte, Ph.D., author of the study, said: The candidate, under the supervision of her Professor Rinse Weersma at the Groningen University Medical Center in the Netherlands, commented: cancer patient We support the role of dietary strategies in initiating ICI treatment and improving patient outcomes and survival. “

The study also found that eating whole grains and legumes reduced the likelihood of developing drug-induced immune-related side effects, such as colitis. was associated with a higher likelihood of immune-related side effects.

“The relationship between ICI response and diet and gut microbiota opens up a promising and exciting future for enhancing therapeutic response. Clinical trials investigating the effects of high-fiber diets, ketogenic diets, and omega-3 supplementation.” is in progress, expanding to different tumor types including as ICI therapy is being done gastrointestinal cancerThese studies have the potential to unlock therapeutic benefits in large groups of cancer patients in the future,” added Laura Bolte.

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High-fiber diet may improve response to immunotherapy in melanoma patients

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For more information:
Volte L, et al. Dietary intake influences response to cancer immunotherapy. Presented at UEG Week 2022. October 9, 2022. Vienna, Austria.

offered by United European Gastroenterology

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