COVID lasts longer in symptomatic SARS-CoV-2 infected

Prolonged COVID, defined as a cluster of one or more symptoms lasting more than 3 months, occurs in approximately 6% of symptomatic SARS-CoV-2 infections, according to a modeling study based on 1.2 million global COVID patients Did.

Estimated 6.2% (95% uncertainty interval) after adjusting for pre-COVID health status [UI] 2.4-13.3) According to Dr. Theo Vos, University of Washington, Seattle, and colleagues at the Global Burden of Disease Long COVID Collaborators, patients with symptomatic infections will have at least one of the three long-term COVID symptom clusters in 2020 and 2021. group in who experienced jam.

This includes:

• 2.2% (95% UI 0.3-7.6) had cognitive impairment
• 3.2% (95% UI 0.6-10.0) had persistent fatigue with body aches and mood swings
• 3.7% (95% UI 0.9-9.6) had persistent respiratory problems

Among people aged 20 years and older, long-lasting clusters of COVID symptoms were more common in women (10.6%, 95% of UI 4.3-22.2) than in men (5.4%, 95% of UI 2.2-11.7). If under 20 years of age, her COVID over time affected her 2.8% (95% UI 0.9-7.0) of her symptomatic COVID patients of both sexes.

The estimated symptom duration was 9 months (95% UI 7.0-12.0 months) in hospitalized COVID patients and 4 months (95% UI 3.6-4.6 months) in non-hospitalized patients. By year 1, his 15.1% of long-stayers with COVID still had symptoms.

Global analysis included Bayesian meta-regression and pooling of 54 studies and 2 medical record databases, incorporating data from 1.2 million individuals with symptomatic SARS-CoV-2 infection from 22 countries .

“We have integrated the available knowledge about the occurrence, severity and duration of three common symptom clusters of COVID over time,” Vos said. Today’s Medpage.

“Importantly, estimates were fixed by comparing differences between those who experienced SARS-CoV-2 infection and those who did not, or by comparing people assessed for symptoms before and after being infected with COVID-19. That’s what we did,” Vos explained.

“All of these symptoms are so common that not correcting them leads to overestimation. , and not correcting for outbreaks in uninfected people.”

“It doesn’t cover the full spectrum of COVID-long symptoms,” Vos acknowledged. It’s about the same as what we’ve measured in people with long-term effects of brain injury,” he noted.

“When we analyzed the largest contributing cohort with the most detailed information, we found that among those who reported that their general health status did not improve and worsened, those who reported similar symptoms at milder levels were excluded. It was suggested that we had almost missed it.

Of the 54 studies included in the analysis, 44 were published and 10 were collaborative cohort studies conducted in Austria, the Faroe Islands, Germany, Iran, Italy, the Netherlands, Russia, Sweden, Switzerland, and the United States. non-hospitalized COVID patients. The cohort study included 10,526 hospitalized and 1,906 non-hospitalized patients.

In addition, data from two US electronic medical records databases (spanning 250,928 inpatients and 846,046 non-hospitalized patients) were used. Data collection is from March 2020 to January 2022 and does not cover the Omicron variant wave.

Analysis is based on clinical cases from the World Health Organization long COVID definitionSymptoms were new-onset and persisted for 3 months after symptomatic SARS-CoV-2 infection.

The estimated proportion of people with at least one of the three long COVID symptom clusters was higher than patients admitted to ICU (43.1%, 95% UI 22.6-65.2) or general wards (27.5%, 95% UI 12.1-47.8) It was big. Not hospitalized (5.7%, 95% UI 1.9-13.1).

More than one-third (38.4%) of long-term COVID-19 patients had duplicates of two or all three symptom clusters.

Vos and colleagues noted that the analysis had some limitations. “95% of the estimated UIs reflect broad, limited and heterogeneous data,” they write.

Algorithms had to be formulated for each study to achieve consistency in cluster definition. Researchers also hypothesized that COVID followed a similar course in all geographic locations.

“We estimate that most cases will recover within a year, but many continue to have symptoms,” Vos noted. No information yet.”