Health
Research identifies genetic variants that affect height
According to researchers, 80% of people’s height differences are determined by genetic factors.photo courtesy Alec Socha/Pixabay
The child’s height answer is usually an estimate based on the average height of the parents.
but australian study Studies of over 5 million people have found over 12,000 genetic variants that affect height.
“80% of height differences in people are determined by genetic factors,” says Loic Yengo, a researcher at the University of Queensland’s Institute of Molecular Biology.
“The 12,000 variants we found account for 40% of height differences, which means we’ve opened the door to using DNA to predict height more accurately than ever before.” ” he explained in a university news release.
About 600 researchers worked on what is said to be the largest ever Genome-wide association studies (GWAS)which analyzes data from 5.4 million people.
“of smaller studyalthough the findings appeared to be scattered across the genome, the enormous sample size of this study indicates that for the first time we have seen clusters of variants associated with height, especially near genes implicated in skeletal growth disorders. means.
Researchers suggest the study could help diagnose potential health problems in children, or help police deduce a suspect’s height from DNA.
“Current, Children’s height is the best predictor But with this genomic data, pediatricians will be able to get more accurate estimates,” Yengo said. It can help initiate further medical investigations and catch potential problems early. ”
The study included more than 1 million people of non-European descent. Although this was more than usual for his GWAS survey, the survey was still biased towards people of European descent.
“Because of the importance of extending the benefits of genetic research to all populations, there are more and more global initiatives to collect more diverse genetic data,” he added.
The research could lead to studies of other gene-controlled traits and diseases, according to the research team. For now, the team plans to identify the remaining genetic factors for height.
“These other factors are harder to spot because of their small impact, and we may need at least 20 million samples to complete that difficult task,” Yengo said. increase.
The findings were published online Wednesday in the journal Nature.
For more information
The American Academy of Pediatrics predict the height of a child.
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