Dementia: Detectable 9 years before diagnosis, could lead to earlier intervention, researchers say

A new study finds it is possible to detect signs of dementia up to nine years before diagnosis, leading to early interventions to reduce disease onset and recruit people to participate in clinical trials of new treatments. There is a possibility.

and study was announced in Alzheimer’s Disease and Dementia: Journal of Alzheimer’s Diseaseresearchers reported the results of an analysis of data from the UK Biobank, a biomedical database of genetic, lifestyle and health information from half a million adults. We have discovered that difficulties may be an early sign of dementia.

There are few effective treatments for other neurodegenerative diseases, including dementia and Parkinson’s disease. It is often diagnosed only when symptoms appear. Until now, it was unclear whether changes in brain function could be detected before symptoms appeared.

For this study, researchers at the University of Cambridge and the Cambridge University Hospitals NHS Foundation Trust turned to biomedical databases to see if there were signs of the disease five to nine years before diagnosis.

Those who developed Alzheimer’s disease were more likely than other adults to fall within the past 12 months. Affected people were more than twice as likely to fall as other adults.

For all conditions studied, including Alzheimer’s disease, Parkinson’s disease, and Lewy body dementia, participants in these conditions reported poorer overall health at baseline.

Noel Swaddiwudhipong of the University of Cambridge said: “Reviewing the patient’s medical history reveals that he had exhibited some cognitive impairment years before symptoms became apparent and prompted a diagnosis.” increase. statement“The deficits were often subtle, but they spanned several facets of cognition.”

The study is a step toward screening those at highest risk so that they can intervene earlier and reduce their risk of disease.

Senior author Dr Tim Littman of the University of Cambridge says the findings could also help identify people who can participate in clinical trials of potential new treatments.

“The problem with clinical trials is that they often recruit diagnosed patients on an as-needed basis, but by this point we know they’ve already gone a long way, and we can’t stop their condition. senior researcher Tim Littman, Ph.D. the author said in a statement. “The sooner we can find these patients, the more likely we are to see if the drug works.”

This study was funded by the Medical Research Council with support from the NIHR Cambridge Center for Biomedical Research.

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