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Psoriasis is not an independent risk factor for heart attacks in terminally ill patients, the study news

Psoriasis is not an independent risk factor for heart attacks in terminally ill patients, the study news


A study published in The American Journal of the Medical Sciences reveals that psoriasis does not affect heart attack risk in patients with a fatal cancer disease. Physiologist Wendy B. Bollag, PhD, said:

“We were asking a population with end-stage renal disease who also had psoriasis, which puts them at an increased risk of heart attack, but they didn’t,” said Borag, the study’s corresponding author.

Researchers at the MCG and Charlie Norwood VA Medical Center compared patients with end-stage renal disease (ESRD) who started dialysis between 2004 and 2015 to the National Renal Data System and had at least two diagnoses of psoriasis. (they hoped two would help). Psoriasis is both underdiagnosed and misdiagnosed, so a proper diagnosis must be ensured), a diagnosis of heart attack or myocardial infarction, and other risk factors for heart disease.

They found that 24% of the 6,283 patients with ESRD and psoriasis — 1,671 also had MI.

These individuals, mostly white males, were undergoing hemodialysis, and researchers expected to find a fairly direct associated risk. Like an independent risk factor for MI, as previous studies have shown.

“But when Waller controlled for these other risk factors, psoriasis decreased. We think the confounding variables influence both exposure to be psoriasis and outcome to be myocardial infarction. Those are the two.” said lead author Naomi Siddiky, an MCG medical student.

Patients with psoriasis are considered to be at increased risk for both chronic kidney disease and ESRD. Inflammation is a key factor in all these conditions, not just heart disease. Many of the same types of immune cells are involved in psoriasis and heart disease.

To get a better understanding of how the disease works on patients, they used the Charlson Comorbidity Index, which essentially picks two out of a long list of problems such as diabetes and hypertension. Predicts 10-year survival for patients with multiple “comorbidities” with Identify conditions that may

This includes problems such as stroke, congestive heart failure, dementia, lung disease, mild liver disease, smoking, cancer and myocardial infarction. In this study, researchers managed all patients except for myocardial infarction, and looked only at conditions that occurred after patients started dialysis for renal failure and before the heart attack.

They adjusted more conditions to focus on the impact of psoriasis on MI in patients with ESRD, likely helping to explain the differences between what they and others found. I think

Other studies are prospective, meaning they follow people to see if they’ve had a heart attack, but the fact that they’ve looked at these conditions retrospectively in a large database suggests that a heart attack could have occurred. It meant better control over the myriad of other factors that could contribute, Borag said.

“We may have controlled for more factors than other studies,” Siddiqui added. may also help explain their findings, which are often undertreated,” she says.

Siddiquee pointed out that previous research logically points to more severe psoriasis causing more internal inflammation. They found evidence to support a relationship between psoriasis and congestive heart failure, and a known independent link between heart failure and heart attack. We recommend that you undergo an annual evaluation of

Psoriasis is widely viewed as a skin condition that can also affect joints, but there is growing evidence that its effects are more widespread in the body. and cardiovascular disease is thought to be a major cause.

With ESRD, which is on the rise in the United States, patients must resort to some form of dialysis or kidney transplantation to restore vital kidney functions, such as filtering toxins from the blood and allowing them to be excreted in the urine. lose.

Most of the patients in the data they looked at were on dialysis. reported that the risk of infection may be reduced when treated to .infection risk and mortality.




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