Health
Monkeypox Research Consortium Launched in UK
The consortium brings together 25 leading researchers and scientists from 12 UK institutions and is part of UK Research and Innovation, the Biotechnology and Biosciences Research Council (BBSRC) and the Medical Research Council. (MRC) with £2 million ($2.2 million) in support. .
The consortium is led by the Pirbright Institute and the MRC-University of Glasgow Center for Virus Research.
enable rapid response
The current global monkeypox outbreak was first confirmed in May 2022. This is the first time that many monkeypox cases and clusters have been reported in non-endemic areas.
The WHO reports that the infection has spread to 106 countries and territories, with 25 confirmed deaths. There have been more than 3,500 confirmed cases in the UK since May, but the number of new cases is now declining.
Researchers in the new consortium will work closely with experts from government agencies such as the Animal and Plant Protection Agency, the United Kingdom Health Security Agency (UKHSA), and the Defense Science and Technology Laboratory (Dstl) to study the current outbreak and bring it to the public’s attention. We will inform you about hygiene measures. UK and internationally.
Professor Bryan Charleston, co-chair of the Pirbright Institute, said: “The impact of the current monkeypox outbreak is devastating. Not only do we have to deal with the current outbreak, but we also need to be well prepared for the next one, because there are so many infected people around the world. is. na
“One of the key ways to do this is by developing rapid tests, which are critical to helping frontline clinicians manage the disease.” na
Professor Geoffrey Smith of the University of Cambridge added: “Few would have predicted that the monkeypox virus would cause a global epidemic in 2022. The ability to respond quickly to this new challenge was not only a quick and welcome response from the UKRI, but research It was also greatly aided by decades of support for Orthopoxvirus from the UKRI and the Wellcome Trust.na
Members of the consortium are:
- Animal and Plant Protection Agency
- Dstl
- gadox
- Guys and St Thomas NHS Foundation Trust
- Imperial College London
- MRC-University of Glasgow Virus Research Center
- Pilbright Institute
- UK Health Security Agency
- University of Birmingham
- Cambridge University
- University of Edinburgh
- oxford university
- University of Surrey
“The information gained from these studies will be valuable in the fight against the monkeypox virus.”na
Consortium scope
The consortium will focus on developing understanding across a number of important areas.
One is to learn from the deployment of a vaccine against monkeypox. To study the efficacy of the smallpox vaccine by following immune responses after primary and secondary vaccination in up to 200 individuals.
Another is to develop new testing and control measures such as:
- Development of highly sensitive point-of-care tests to expedite diagnosis, such as the lateral flow test and the LAMP* test. Lateral flow test development is conducted using Global Access Diagnostics (GADx) to develop products that are later manufactured at scale and used clinically around the world, including in low- and middle-income countries.
- Potential drugs to treat monkeypox in human cells in the laboratory will be screened to determine which drugs can be developed for further testing.
- Study viruses, how they infect humans, and their susceptibility to immune responses to identify future therapeutic targets.
This partnership will also reveal the viral genome and its evolutionary features, as well as the links between viral transmission and changes in disease. We also seek to understand the human immune response to both viruses and vaccines. As well as identifying animal reservoirs and potential routes of transmission between animals and humans.
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