Health
Painkiller use after COVID-19 vaccination does not adversely affect antibody responses
In a recent study posted on medrex sib*Preprint server, University of Arizona researchers evaluated the relationship between antibody response and analgesic drug use following coronavirus disease 2019 (COVID-19) vaccination.
study: There is no evidence that post-COVID-19 vaccination painkillers adversely affect antibody responsesImage Credit: Natalia Dolgosheeva / Shutterstock
Background
COVID-19 vaccine is expensive Effectiveness against clinical disease induced by the ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).However, emerging variants like SARS-CoV-2 Omicron and its substrains are largely evaded Neutralizing antibody Produced by vaccination. Therefore, bivalent messenger ribonucleic acid (mRNA) booster vaccination was updated to better neutralize the BA.4/5 strain. However, reactogenicity observed in response to these vaccines may have a detrimental effect on patient willingness to accept booster shots.
However, COVID-19 animal models have shown that non-steroidal anti-inflammatory drugs (NSAIDs) significantly reduce antiviral antibody responses, as an accurate correlate of protection against SARS-CoV-2 infection. Works. These mild adverse events may be mitigated to some extent by over-the-counter pain relievers. However, it is still unclear whether mRNA immunity causes the same inhibitory effects in humans.
About research
In the current study, researchers surveyed COVID-19 vaccinees regarding pain medication use and compared the results to SARS-CoV-2 spike (S)-specific antibody levels.
The team evaluated survey data related to pain medication use from March 15, 2021 to March 22, 2022. The survey was answered by his 2,354 her COVID-19 vaccinees included in a statewide antibody testing program conducted by the University of Arizona. Self-reported vaccination history, use of analgesics within 48 hours after administration of two mRNA-1273 or BNT162b2 vaccines, and antibodies elicited against the SARS-CoV-2 S receptor binding domain (RBD) were examined. was given. One-way analysis of variance (ANOVA) was also performed using the t-test statistic.
result
Those who did not take analgesics had significantly lower levels of RBD-specific antibodies than those who took NSAIDs or acetaminophen. there was no real difference. Interestingly, analgesic use was associated with increased, but not decreased, levels of anti-spike antibodies.
RBD levels were statistically significantly higher in those who did not respond to the survey than in those who did. most commonly seen in people with After vaccination, his 95% of subjects were seropositive, but only a minority fell below this cutoff. Those taking NSAIDs and experiencing these three symptoms had a higher seropositivity rate than those not taking analgesics.
A significant proportion of NSAID users and those who did not use pain medication reported fatigue and muscle pain. We found that a lower proportion of participants experienced headaches than aminophen users. Unfortunately, the observational design of this study precluded direct evaluation. However, the most rational explanation for increased antibody levels was that the inflammation and adverse events were related to increased antibody rather than pain medication use.
Overall, the study results provided no evidence that post-COVID-19 vaccination analgesic use adversely affected antibody responses.
*Important Notices
medRxiv publishes non-peer-reviewed, preliminary scientific reports and should not be considered conclusive, to guide clinical practice/health-related actions, or to be treated as established information .
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