Health
Drug duo treats stubborn urinary tract infections
Comparing new and old treatments, newer drug combinations have proven more effective against complex urinary tract infections, especially persistent drug-resistant infections.
Explaining the results of the study, researchers in the ALLIUM Phase 3 clinical trial said that the combination of cefepime and emetazobactam was effective against complex urinary tract infections and acute pyelonephritis, a bacterial infection that causes inflammation of the kidneys. (AP) was shown to be more effective in both treatments. Standard treatment with a combination of piperacillin and tazobactam.
Urinary tract infections are considered complicated when associated with risk factors such as fever. sepsisurinary tract obstruction, or catheter-increase the risk of antibiotic therapy failure.
“This new antibiotic was superior to standard treatments,” says Keith, professor of medicine and director of the Division of Allergy, Immunology and Infectious Diseases at Rutgers Robert Wood Johnson School of Medicine. Kay says.
“This represents an exciting option for treatment,” said lead author, Journal of the American Medical Association.
The drug combination also combats an often dangerous category of bacterial diseases caused by pathogens known as extended-spectrum beta-lactamase (ESBL) infections, named after the enzyme the bacteria produces, Kaye adds. rice field. ESBL-producing bacteria cannot be effectively killed by many antibiotics traditionally used to treat infections, such as penicillins and cephalosporins.
“We are looking for antibiotics that are effective against resistant bacteria. ESBLand we’ve found this new combination to be very effective,” says Kay.
The trial was conducted from September 2018 to November 2019 at 90 locations across Europe, North and Central America, South America and South Africa. Over 1,000 patients participated in this trial.
Approximately 79% of patients receiving the new combination of cefepime and enmetazobactam successfully treated their disease, as opposed to 58.9% of patients receiving conventional therapy with piperacillin and tazobactam.
Of the 20% of patients in the overall group belonging to the subset of ESBL infections, 73% of patients receiving cefepime and enmetazobactam achieved clinical cure compared to 51% of patients receiving standard care was cured.
The antibiotic cefepime is a fourth-generation cephalosporin approved for use in the 1990s and available generically. Enmetazobactam, an drug manufactured by French biopharmaceutical company Allecra Therapeutics, is a beta-lactamase inhibitor, meant to attack beta-lactamases, including a class of enzymes produced by ESBL-producing bacteria. .
This drug combination has been granted Qualified Infectious Disease Product and Fast Track designation by the U.S. Food and Drug Administration (FDA). Kaye said he expects the company to file for FDA approval early next year.
Over 2.8 million Antibiotic resistant infections The U.S. Centers for Disease Control and Prevention (CDC) reports that it occurs each year in the United States, killing more than 35,000 people. In his 2019 study on antibiotic resistance, the CDC characterized her ESBL as a serious threat to human health.
Source: Kitta McPherson Rutgers University
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