Health
A new Covid-19 XBB subvariant has arrived in India. How worried should I be?
The emerging Covid variant has been expected for some time, but Reported in various parts of the country, mainly in Maharashtra. Winter is about to start, but it’s a wait and see to see if there’s a new wave coming. COVID-19 Infection. Dr. Sanjay Pujari, an infectious disease expert and member of the Indian Council for Medical Research (ICMR), said that based on his experience in Singapore, the vaccine is new for the severe disease associated with his XBB subtype. He said it could work well for prevention.
fast-moving variant Omicron have been reported – even more so in Maharashtra. What are these Covid variants?
Omicron subvariants XBB, BQ.1 have been reported. XBB is a recombination (combination) of two Omicron BA.2 subvariants (BA.2.10.1 and BA.2.75). Many mutations on the surface of the virus are involved in immune escape from neutralizing antibodies that target the spike protein. According to WHO (as of 12 October 2022), Omicron is now the predominant variant in global circulation, accounting for more than 98% of sequences shared with his GISAID since February.
Where else has this Covid variant been reported in India and around the world? Was it first detected here?
According to the WHO weekly epidemiological update on COVID-19 (26 October 2022), 390 omicron descendant lineages and 48 recombinants have been identified. XBB and XBB.1 have been reported in 1,453 genome sequences from 35 countries including Singapore, India, Bangladesh, Australia and the United States. Cases have started to decline since last week, but are linked to a surge in COVID-19 in Singapore.
Is it cause for concern? Could it cause a surge?
Like other viruses, the SARS-CoV2 virus is expected to mutate and change over time. Some of these mutations may not be important, but according to WHO, the changes can influence the characteristics of the virus, such as how easily it spreads and the severity of associated illness.
The XBB subvariant is probably the most immunoevasive variant to date, especially to avoid neutralizing antibody responses induced by vaccination or previous infection. This can lead to increased infections. However, there are no data linking it to more serious illnesses. Based on the experience in Singapore, it appears that the vaccine may work well to prevent severe illness associated with this subspecies. Resistance to monoclonal antibodies that prevent progression to HIV has also been noted.
How many cases and symptoms so far?
XBB and XBB.1 have been reported in 1,453 genome sequences from 35 countries. Because of immune evasion properties, reinfections and breakthrough infections can occur, but are mostly mild and cause upper respiratory symptoms.
What are the effects of vaccines?
Very preliminary evidence suggests that vaccines may help prevent serious illness. Further information is expected soon from the WHO Technical Advisory Group Statement on Virus Evolution.
I have Covid fatigue. With so many new subvariants, should boosters be used? What about mRNA?
Yes, you should take boosters as they can help prevent severe illness and hospitalization. Vaccines (including vaccinations) can help prevent serious illness. Therefore, taking boosters is especially important for those at high risk of severe illness. Currently, no mRNA vaccine is available in India.
What precautions should be taken?
For the elderly, especially those with chronic comorbidities and immunosuppression, preventive dose catch-up is essential. Masking should continue, especially in closed, congested environments without adequate ventilation. Staying at home is also important in case of acute respiratory illness. Increased surveillance, including genome sequencing, should continue.
why Dr Pujari
Doctor Sanjay Pujari, MD, FIDSA is the Director and Chief Consultant of the Institute of Infectious Diseases., PuneHe is also a member of the Indian Council for Medical Research (ICMR)-Covid 19 Task Force.
Sources 2/ https://indianexpress.com/article/lifestyle/health-specials/covid-19-xbb-sub-variant-india-8235722/ The mention sources can contact us to remove/changing this article |
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