Health
Paxlovid may help prevent long-term COVID, study says
As the world plunges back into pandemic winter, 4 million people Suffering from long COVID brain fog, headaches, chest pain, and other terrible symptoms. preprint research The Veterans Health Administration (VA) offers some hope for reducing the risk of developing debilitating conditions.
The study found that antiviral drugs pax robidAimed at treating and relieving symptoms of COVID-19.This study is a preprint posted online over the weekend, so it is still subject to peer review.
[Related: Long COVID could be keeping as many as 4 million Americans out of work.]
In this study, long-term COVID was defined as the development of one or more symptoms (such as heart problems, blood problems, fatigue, or difficulty breathing) one to three months after testing positive. The team analyzed the electronic medical records of 56,340 patients. All patients had at least one risk factor for severe reaction to COVID-19 infection. The analysis showed that 9,217 patients who took paxlobid within 5 days of testing positive had a broader spectrum of COVID-19 approximately 90 days later than the 47,123 patients who did not receive antiviral or antibody therapy. They found they were 26% less likely to develop later symptoms.
All patients in the study tested positive for COVID-19 between March 1 and June 30, 2022. Subspecies of Omicron It was the dominant stock for COVID. The study also found that the benefits of taking paxlovid also apply to unvaccinated, vaccinated, and his repeat COVID-19 infections. All groups similarly reduced his long-term COVID onset with antiviral medications.
For those medically eligible to take paxlovid (elderly or with certain medical conditions), the risk of hospitalization or death is reduced. blocking receptor Prevents the virus from binding to healthy cells and making copies of itself.
“We know that one of the key factors predicting the longevity of COVID is the detectable virus in the bloodstream at the time of infection,” says Peter Chin, an infectious disease physician at the University of California, San Francisco. -Hong told NPR“So it stands to reason that interventions that prevent the virus from making more copies of itself will lead to a lower risk of COVID in the long term.”
[Related: Long COVID can manifest in dozens of ways. Here’s what we know so far.]
The authors point to this study as another motivation for patients to take paxlovid as soon as possible after they become ill. “Pax Rovid’s Rebound” Recurrence of symptoms or positive test results.A small percentage of patients (approximately 1 to 2 percent Pfizer’s clinical trials) have experienced this, but the focus is on President Joe Biden When Anthony Fauci similarly need more data In the case of rebounds, concerns increased.a longer course of treatment It is being investigated as a possible method to prevent drug rebound.
“For people who are already eligible to use paxlovid, the choice is really clear to me,” said Ziyad Al-Aly, senior author of the study and director of research and development at VA St. Louis Health Care System. rice field. new york times“Will I have a metallic taste, side effects of paxlobid, or rebound? Yes. Suggestive data have been proven. And now, in the post-acute phase, it also shows risk reduction.”
In addition to the study’s status as a preprint, it is also limited by sample size demographics.We studied primarily white men, so paxlovid benefits may vary for other demographic groups. told NPR They also hope these results can be replicated Experimental randomized controlled trial.
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