Male hormone levels can predict long-term health

A study led by the University of Nottingham shows that levels of the types of hormones produced by the testicles during puberty can predict a man’s health later in life.

Insulin-like peptide 3 (INSL3) is produced by mature Leydig cells and also produces testosterone in the adolescent testis.

Unlike testosterone, INSL3 levels rise from 18 to 20 years of age and then remain largely the same throughout life, reaching individual average levels for many years and declining at a rate of approximately 15% per year after age 40. drops to This means that if a man’s level is low in his 20s, it will remain low throughout his life.

Although its known association with aging makes INSL3 an interesting biomarker, its specific relevance to health was previously unknown. To investigate further, Ravinder Anand-Ivell, a professor at the University of Nottingham, and colleagues examined whether INSL3 levels were associated with age-related diseases in a cohort of 3000 men aged 40–79 years at the time of recruitment. was analyzed.

“The ultimate goal of aging research is to reduce the fitness gaps that emerge with aging. , is essential to ensure that interventions can be found to ensure that people not only live longer, but live healthier lives as they age.

Write to journal The forefront of endocrinologythe authors reported that the levels of INSL3 in the blood of the men in the study varied widely, with levels of up to 10-fold differences observed between individuals. It has been associated with several age-related diseases, including diabetes and cardiovascular disease.

Low INSL3 was associated with an increased risk of seven out of nine comorbidities, including cancer, diabetes, cardiovascular disease, and low bone density in the elderly. and found an association between hypertension.

“Now that we know the important role this hormone plays in predicting disease and how it varies in men, we turned our attention to finding the factors that most influence levels of INSL3 in the blood. says lead author Richard Ivell, who is also a professor at the University of Nottingham.

“Preliminary studies suggest that nutrition at an early age may play a role, but many other factors, such as genetics and exposure to environmental endocrine disruptors, may be involved. I have.”

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