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GSK says 65% more effective long-acting HIV prophylaxis than Truvada


(Reuters)-UK GSK said Tuesday that every two months an injection of cabotegravir was 65% more effective in preventing HIV infection than the daily oral dose of Gilead’s Truvada. It was.

File Photo: A small bottle labeled with the “Vaccine COVID-19” sticker and a medical syringe is shown in this figure taken on April 10, 2020. Reuters / Dado Ruvic / Illustration / File Photo

As the final data from the study presented at the Virtual AIDS Conference showed, HIV incidence-or the number of people infected during the period-was 0.41% by injection and 1.22% in Truvada, Gilead. ..

Truvada is currently the standard treatment for HIV prevention, but GSK wants to challenge its advantage by creating shorter, longer-term regimens and less toxic alternatives through the ViiV Healthcare unit.

“This advance has the potential to transform HIV prevention. It offers the convenience of reducing the dosage from daily to six times a year,” Kimberly Smith, Head of Research and Development at ViiV Healthcare. Says.

Truvada generated $2.8 billion in revenues from both treatment and prevention of HIV infection last year. This is a deadly condition that causes AIDS and, unless subdued, significantly weakens the immune system.

About 75 million people worldwide are infected with HIV, and about 32 million have died since the beginning of the 1980s. (

Cavitogravir and oral oral medications are well tolerated and HIV-infected in a study conducted on men having sex with other men and transgender women having sex with men. There are risks, ViiV said.

Of the participants, 80% reported injection site pain or tenderness, compared to 31% of subjects in another study department who received placebo injections.

ViiV, which has a small stake in Pfizer and Shionogi, also said two-thirds of adults in the study were under the age of 30, and 12% were transgender women.

ViiV uses the data for regulatory submissions.

Report by Pushkara Alipaca of Bangalore. Editing by Anil D’Silva


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