Health
Risk of cerebral palsy in IVF babies cut in half over the last two years
Researchers report that cerebral palsy in IVFs has decreased by more than 50% over the last 20 years.
The overall risk of cerebral palsy in children devised via assisted reproductive technology (ART) dropped from 0.9% to 0.3% from 1990 to 2010, but among naturally devised children The risk of sterility remains stable at the Copenhagen University Hospital in Infertility Clinic Ligshospitalé Denmark.
Although the prevalence of cerebral palsy among IVF singletons decreased during the study period (from 8.5 to 2.8 per 1,000 births), it was stable in IVF twins, indicating that multiple pregnancies increase risk. European Society for Human Reproduction (ESHRE) Virtual Conference..
“The high birth rate of twins after ART is causing criticism for serious complications related to twin pregnancy, including cerebral palsy,” Spangmose said in a presentation.
“Multiple embryo transfer is still the standard of care in many countries,” she said in a press release. “Our findings underscore that single embryo transfer and singleton birth should be encouraged around the world.”
so Large-scale cohort study published in 2005Researchers have found that the risk of cerebral palsy is significantly increased among infants with ART pregnancy. Although absolute risk is small, cerebral palsy has become the most common developmental birth defect associated with in vitro fertilization.
A current study by Spangmose and colleagues shows that the risk of IVF-induced cerebral palsy decreased with increasing rates of single embryo transfer, but twin risk did not change.
“The underlying cause of CP is related to multiple pregnancies,” said Alan Penzias, a reproductive endocrinologist at Boston IVF and an associate professor of obstetrics, gynecology and reproductive biology at Harvard Medical School. It was “In other words, twin pregnancies are more common in children with CP than singleton pregnancies.”
Penzias, who was not involved in the study, said the study was able to discriminate risks between both singleton and twin pregnancies in ways that previous studies did not. “This study highlights the relevance of single embryo transfer in in vitro fertilization,” he said. MedPage today..
Spangmose and colleagues obtained data from the Nordic Art and Safety Commission (CoNARTaS) cohort, which includes information from national ART and patient registries from Denmark, Finland and Sweden. The data covered approximately 55,000 IVF babies and more than 2 million spontaneously pregnant children. The researchers grouped the data by birth year during the periods 1990-1994, 1995-1999, 2000-2004, and 2005-2010. Adjustments were made for mother age, birth history, child gender, country, and year of birth.
Overall, 0.6% of IVFs and 0.3% of spontaneous pregnancy were diagnosed with cerebral palsy. Of the babies pregnant via ART, about 37,000 were singleton pregnancies, 17,000 were twins, and about 800 were higher multiples.
The risk of cerebral palsy in babies who received ART was approximately twice that of babies who were considered spontaneous (aOR 1.93, 95% CI 1.71-2.17). After multiple adjustments, risk estimates were attenuated but significantly increased by ART (aOR 1.18, 95% CI 1.04-1.34).
Risk was higher for ART-invented singletons (aOR 1.32, 95% CI 1.10-1.57), but was similar for both IVF and spontaneously pregnant twins.
Spangmose and colleagues acknowledged that this observational study could be affected by residual confounding, despite adjusting for key covariates.
Disclosure
Spangmose and colleagues have not revealed a link to the industry.
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