Health
Researchers have discovered a new mechanism that allows cancer cells to move throughout the body
An international team of researchers has discovered a new mechanism that allows cancer cells to move throughout the body, providing a potential new target to stop metastasis, which is responsible for 90% of cancer deaths.
In a survey published in Nature, the team identified that cancer cells migrate faster when surrounded by a thicker liquid. This is a change that occurs when lymphatic drainage is compromised by the primary tumor.
This is the first time that the viscosity of extracellular fluid has been investigated in detail. Now that the viscosity of the fluid has been found to signal cancer cells to move in a certain way, drugs are used to essentially short-circuit that signal pathway, slowing or stopping the cancer cells. It may be possible. ”
John D. Lewis, Professor of Translational Oncology and Bird Dog Chair, University of Alberta School of Medicine and Dentistry
The Lewis lab was invited to join a project led by researchers at Johns Hopkins University who specialize in real-time imaging of human cancer cells using the placenta-like chorioallantoic membrane of a fertilized chicken egg. Because I had the knowledge.
“I think we are the world leader in this type of imaging,” says Lewis. “Our contribution to this study was to show with great precision that cancer cells alter gene expression and become more aggressive when they encounter an increase in the viscosity of the surrounding fluid. These cells continue to be more aggressive even when the .
“We then showed that when this signaling pathway is disrupted in cancer cells, their ability to escape the bloodstream and metastasize is altered,” says Lewis.
This is the third paper published by an international research team. Lewis credits a large part of his team’s work to his senior researcher, Konstantin Stoletov. He warns that drug development and testing could take anywhere from 10 to 15 years once a new therapeutic target is identified.
sauce:
Journal reference:
Bella, K. and others. (2022) Extracellular fluid viscosity promotes cell migration and cancer dissemination. Nature. doi.org/10.1038/s41586-022-05394-6.
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