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Severe COVID ages brain tissue at the molecular level: study

Severe COVID ages brain tissue at the molecular level: study

 


December 12, 2022 – The brain tissue of people who died of severe COVID-19 was similar to that of people over the age of 71, allowing researchers at Harvard Medical School to predict that recovered COVID-19 patients may be neurologically ill. Seeking follow-up care was recommended.

A new study adds molecular findings to growing evidence that severe and prolonged COVID causes thinking problems, sometimes called “brain fog.”

“Our study is the first to show that COVID-19 is associated with molecular features of brain aging,” said Beth Israel Deaconess Medical Center (BIDMC) and Department of Pathology, Harvard Medical School. Instructor and author Dr. Maria Mavraki said: news release“We found a striking similarity between the brains of COVID-19 patients and the brains of older people.”

Researchers examined 54 brain tissue samples from people aged 22 to 85. She compared samples of people who died of severe COVID-19 with brain tissue from people of the same age and sex with no history of neurological or psychiatric illness. In another comparison, severe he compared people with both COVID and Alzheimer’s disease to patients with Alzheimer’s disease but not COVID-19. A third evaluation set was samples from people with and without her COVID-19 who had a history of intensive care or mechanical ventilation.

“Although we found no evidence that the SARS-CoV-2 virus was present in brain tissue at the time of death, we did find patterns of inflammation associated with COVID-19,” said postdoctoral study co-author Jonathan says Dr. Lee. Fellow of BIDMC and his School of Medicine at Harvard. “This suggests that this inflammation may contribute to the aging-like effects observed in the brains of COVID-19 and long-her COVID-19 patients.”

The study was published in a journal natural aging this month.

“Given our findings, we advocate for neurological follow-up of individuals who have recovered from COVID-19 to modify risk factors to reduce risk or to assess age-related neurological conditions and cognitive function. It suggests that there is potential clinical value in delaying the onset of decline,” said the researchers. I have written.

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2/ https://www.webmd.com/brain/news/20221212/severe-covid-ages-brain-tissue-molecular-level-study

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