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End of IVF Endometrium Scratch Road?

 


Endometrial scratches were not successful for the first time in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in a randomized, open-label study.

Patients with Endometrial Scratch-in it There is a slight scar on the endometrium To Promote Embryo Implantation-There was a comparable birth birth rate to patients receiving normal care (38.4% vs. 37.1% respectively), Dr. Mosta Famethowary at Sheffield Teaching Hospital and University of Sheffield

Endometrial scratches have been done before AskedThese test results provide conclusive evidence that treatment does not benefit first-time IVF/ICSI patients. Virtual meeting of the European Society of Human Reproduction..

Clinical pregnancy rates for women with endometrial scratch arms were also similar to those in the control group (42.6% vs. 40.6%, respectively).

“Our study is the largest and most definitive study in women receiving the first IVF treatment,” Metowaley said in a press release. “It’s time to break this convention,” he said.

Dr. Richard Paulson, MD, director of the USC Fertility in Los Angeles, says that scratching the endometrium is “biologically relevant,” but there are many problems with its practice.

“This is one of the many problematic add-ons we’ve seen in the field of infertility these days,” Paulson, who was not involved in the study, said. MedPage today.. He added that while many US healthcare providers have abandoned this treatment, the results of this trial may have broader implications for other countries.

“I think this study should put an end to endometrial wounds in the treatment of infertility,” Paulson said.

Over 83% of New Zealand, Australian and British doctors Endometrial scratch recommended, According to a survey released in 2016. The effectiveness of this treatment has been disputed, but some providers still recommend it to patients with IVF/ICSI.

In the current trial, Metowaly and colleagues aimed to assess whether endometrial scratches in mid-luteal phase would improve the chances of giving birth to patients with first-time IVF/ICSI. From 2016 to 2019, the group recruited women from 16 fertility centers in the UK. Inclusion criteria were below 37 years of age and were expectations of good outcomes. Approximately 1,050 women were included in the trial. The average age was 33.

Although the primary outcome of the trial was birth rate, researchers also evaluated clinical pregnancy rates, implantation rates, ectopic pregnancy rates, miscarriage rates, preterm birth rates, and stillbirth rates.

Differences in live birth and clinical pregnancy rates between endometrial scratches and control groups were not significant. All other secondary and adverse outcomes were similar between the two groups.

Metowerley and colleagues admitted that the control group did not receive sham treatment, but the group explained that the open-label design did not affect the test results. Moreover, this survey may not be generalizable to populations with different sociodemographic profiles than the UK.

  • Amanda D’Ambrosio Reporter for the MedPage Today enterprise and research team. She covers obstetrics and gynecology and other clinical news and writes about the US healthcare system. Follow

Disclosure

This study was funded by the National Institutes of Health.

Metwally and colleagues have not revealed a link to the industry.



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