Health
Researchers identify cause of serious illness in children — ScienceDaily
The origin of the serious cancer-like disease LCH was identified by researchers at the Karolinska Institutet in collaboration with Karolinska University Hospital.Findings published in scientific immunology It may lead to new targeted therapies.
Langerhans cell histiocytosis (LCH) is a serious type of cancer-like disease that primarily affects children and can be fatal in severe cases. In Sweden, 5 to 10 of her children get the disease each year, usually before the age of 10.
LCH is a disease in which cancer mutations occur in the immune cells responsible for detecting and eliminating cancer cells.
“The origin of LCH cells has been debated for decades. Some researchers believe it does,” said Egle Kvedaraite. At Karolinska Institutet, he is a physician and researcher in the Department of Medical Biochemistry and Biophysics and the first author of the new study.
Researchers at the Karolinska Institutet, along with scientists from the Singapore Immunology Network and the University of Newcastle, were able to show that both theories are close to the truth. The researchers combined so-called single-cell sequencing, microscopy of samples, and tracking of cells specifically from patients recruited from Karolinska University Hospital.
They found that mutated LCH cells had properties similar to both monocytes and dendritic cells.
“Today, we know that DC3 has a developmental pathway that is distinct from other dendritic cells and monocytes, and knowledge of this was essential to our research.
Researchers have found that different cell types communicate with each other to facilitate the development of LCH, thereby producing a self-reinforcing effect.
“Among treatment options for LCH, targeted therapy can be successfully applied, but disease relapses when targeted therapy is discontinued. This is a serious challenge for patients. not,” says Egle Kvedarite.
This new understanding of the origin of this type of cancer may contribute to the development of new targeted therapies.
“This discovery may lead to treatments aimed at eliminating diseased cells,” said Egle Kvedaraite.
This study was funded by grants from the Erik and Edith Fernström Foundation for Medical Research, Swedish Childhood Cancer Foundation, Histiocytosis Association, VIVA Foundation for children with Cancer, Wellcome Trust, CRUK Biomarker Project, Histio UK, and Bright Red. rice field.
Story source:
material provided by Karolinska Institute. Note: Content may be edited for style and length.
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