BioNTech Begins Clinical Trial of mRNA-Based Malaria Vaccine Candidate
Berlin, December 23 (Reuters) – BioNTech (22UAy.DE) has started a first-in-human Phase 1 clinical trial of its BNT165b1 malaria vaccine candidate using mRNA technology, the German company announced on Friday.
The phase 1 trial will enroll 60 volunteers with no history of malaria in the United States to evaluate the vaccine candidate at three dose levels, BioNTech said in a statement.
BNT165b1 is the first vaccine candidate in BioNTech’s malaria project, which aims to develop a highly effective mRNA vaccine and establish vaccine production in Africa.
The company said it will initially evaluate different antigens of the parasite that causes malaria over the next few months and select a multi-antigen vaccine candidate to proceed to late-stage trials.
Malaria infects millions of people each year and kills hundreds of thousands, mostly young children in the poorest parts of Africa.
Mosquirix, the world’s first and only licensed malaria vaccine, was developed by GSK Plc. (GSK.L) Despite years of clinical trials in several African countries, it is only about 30% effective. Moreover, the lack of funding and commercial viability makes sabotaged GSK’s ability Generate as many shots as you want.
The mRNA vaccine, which has come into the spotlight as pharmaceutical companies race to develop vaccines against coronaviruses, prompts the human body to make proteins that are part of the pathogen, triggering an immune response.
Written by Miranda Murray, edited by Louise Havens
Our criteria: Thomson Reuters Trust Principles.
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