Health
New blood test could diagnose Alzheimer’s even if you don’t have symptoms
Researchers have found the best blood test to detect relevant treatment effects and hasten diagnosis.
New Delhi,Has been updated: December 28, 2022 13:53 IST
This disease involves the parts of the brain that control thought, memory, and language. (Photo: Getty)
India Today Webdesk: As science continues to advance, scientists around the world are working to find better treatment strategies for Alzheimer’s disease. A new study has identified tests that may help diagnose neurological conditions in their early stages.
Researchers have also found another blood test that’s perfect for detecting relevant treatment effects. This can speed diagnosis and treatment and slow disease progression.
According to the US-based CDC, Alzheimer’s disease is the most common type of dementia and is progressive in nature, starting with mild memory loss and ending with loss of the ability to hold a conversation and respond to the environment. is. This disease involves the parts of the brain that control thought, memory, and language.
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A research team led by Prof. Oskar Hansson of Lund University and Prof. Kai Brenow of Gothenburg University analyzed blood tests and found that multiple, even in asymptomatic participants, were sufficient to identify Alzheimer’s disease pathology. found a blood biomarker. It was published in the journal Nature Medicine.
They analyzed blood tests for Alzheimer’s disease pathology and neurodegeneration in 575 individuals from the BioFINDER cohort. Plasma testing was repeated for up to 6 years, along with cognitive testing and magnetic resonance imaging, in 242 participants. and associated with increased brain atrophy typical of early Alzheimer’s disease.
According to Lancet, plasma tau phosphorylated at threonine 217 (p-tau217) and threonine 181 (p-tau181) are associated with Alzheimer’s disease tau pathology.
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This test could be used as a strategy to select the correct individuals for new disease-modifying trials, a task that currently requires expensive molecular imaging techniques or a lumbar puncture. It is well suited for identifying Alzheimer’s disease pathology and monitoring disease progression, and therefore has multiple roles in clinical trials,” said lead author of the study, Dr. Nicholas Ashton of the University of Gothenburg, in a statement. I’m here. .
This study shows that phosphorylated Tau 217 uniquely positions itself as the test of choice for monitoring patients in both clinical and laboratory settings due to its longitudinal association with the development of Alzheimer’s disease. I’m here.
“In addition to improving clinical trial design, the new blood test will revolutionize early-stage diagnosis of Alzheimer’s disease. In addition, phospoho-tau217 will monitor individual patient response to disease-modifying therapies in clinical practice. It may be used in the future to do so,” added Oskar Hansson.
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