Health
Cheap and widely available hep C drug shown to reduce mortality in Covid-19 patients
Two Cheap and Widely Available Hepatitis C Drugs Reduced Inpatient Mortality Coronavirus, Shows the results of three small studies.
The drugs-Sofosbuvir and Daclatasvir-were given to three groups of patients hospitalized with the Iranian virus. After 14 days of treatment, 94% of patients taking concomitant medication showed signs of recovery, compared to 70% of those receiving standard treatment.
Mortality from drug combinations was 5%, while those on standard care had 20%.
“People who took the drug combination had significantly faster clinical recovery and discharge rates, and faster survival,” said Dr. Andrew Hill, a senior visiting researcher and researcher at the University of Liverpool. It was
Therapies work by binding to one of the viral proteins, interfering with their ability to replicate. Laboratory studies have shown that Daclatasvir is the most effective of the two because it penetrates the lungs where Covid-19 infections often concentrate.
One of these smaller trials was not randomized, so researchers who presented results this week at the International AIDS Association Covid-19 Scientific Conference emphasized that the results should be considered preliminary. did.
“I don’t want to get tired of this because it’s early data,” he added.
Five randomized controlled trials have been established in Iran, Brazil, Egypt, and South Africa to test the combination as both therapeutic and prophylactic, and the researchers hope to recruit 2,000 patients and healthcare workers.
They want to see the data by October, and if the combination is successful, it could be approved for worldwide use.
Dr. Thiagosusa, one of the Brazilian researchers, said: “The combination of Sophosbuvir and Daclatasvir has an already established safety profile in the treatment of hepatitis C.
Researchers know that the treatment is safe and well tolerated because it is well established. It is also inexpensive and widely available. A 14-day treatment course in India, Pakistan, and Egypt costs just $7.
“This can be rolled out quickly because there are literally millions of doses for people,” said Dr. Hill.
Researchers are meeting with the World Health Organization, whose solidarity trials are testing different treatments around the world, but the agency sees more data before including drug combinations in the trials. I want to
Dr. Hill said he didn’t want to see another person Status of hydroxychloroquine type -Early hopes that were later canceled, and promotion by US President Donald Trump triggered drug execution.
“I don’t want this drug to be raging. It takes 10 weeks before we can properly see if it works.”
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