Health
Experts find pancreatic cancer tumors may respond to immunotherapy combinations
There is renewed hope that one of the most deadly forms of cancer may eventually respond to certain forms of immunotherapy.
Texas researchers have found that a three-pronged immunotherapy combination offers promising preliminary findings in targeting pancreatic cancer tumors.
Pancreatic cancer, which occurs when abnormal cells in the pancreas grow out of control to form tumors, is diagnosed in more than 600 people each year in the country, according to the Irish Cancer Society.
Approximately 9 out of 10 patients have the most common disease, adenocarcinoma.
It is considered one of the most serious forms of cancer, meaning it is often asymptomatic at first and very advanced once diagnosed. Most patients have a poor prognosis.
Famous pancreatic cancer sufferers include legendary opera singer Luciano Pavarotti, British actor Alan Rickman and Hollywood star Patrick Swayze.
With former Glasgow Celtic forward Frank McGarvey dying in recent days shortly after announcing he had pancreatic cancer, Italian footballer great Gianluca Vialli is now undergoing treatment for a second illness. I am receiving
Apple founder Steve Jobs suffered from a rarer form of pancreatic cancer than the more common adenocarcinoma.
Researchers at the University of Texas MD Anderson Cancer Center have announced that they have discovered a new combination of immunotherapies that has shown promising results in their studies.
Its triple combination immunotherapy approach targeted both T-cell and myelosuppressive cell checkpoints.
Corresponding author and professor of cancer biology Ronald DePinho said: Vulnerable to appropriate combination therapy.
“Furthermore, the presence of these targets in human pancreatic cancer specimens increases the likelihood that such therapeutic combinations will one day help patients.”
Targeting three types of cells and proteins resulted in complete tumor regression and improved overall survival in 90% of preclinical models. In a more rigorous laboratory model that develops multiple, highly treatment-resistant spontaneous tumors, this combination achieved complete tumor regression. More than 20% of cases, researchers said.
DePinho added: “These are encouraging results, especially given the lack of effective immunotherapeutic options in pancreatic cancer, suggesting that pancreatic cancer, and possibly other non-immunogenic cancers, may ultimately be a candidate for combination immunotherapy. We are optimistic that we may be vulnerable to
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